- Hypertension or high
blood pressure is the increased pressure of the blood in the arteries.
- Beta - blockers, calcium channel blockers, angiotensin
antagonists and thiazide diuretics are some of the commonly prescribed blood
- A research team from the University of
Glasgow has studied the increased risk of mood disorders being associated with
blood pressure medications.
- The findings suggested that
angiotensin antagonist drugs were found to be the repurposed treatment for
hypertension with a lower risk of mood disorders.
A new research study
published in the American Heart Association's journal Hypertension
found that commonly prescribed blood pressure medicines
may increase the risk of depression
or mood disorders.
Hypertension or high blood pressure
is the increased force exerted against the walls of
the arteries during pumping of blood. High blood pressure may increase the risk
of heart diseases and stroke.
‘Commonly prescribed blood pressure medicines may increase the risk of depression and bipolar disorders.’
According to the Centers
for Disease Control and Prevention, about 75 million people in America have
hypertension and around 410,000 people died due to high blood pressure in 2014.
In India, it is
estimated that around 214 million people would be affected by hypertension in
beta - blockers, calcium channel blockers, angiotensin receptor antagonists
might help in the treatment of high blood pressure.
Research Study on the
Risk of Mood Disorders with High Blood Pressure Medicines
A research team from the
University of Glasgow has collected data from 525,046 people between the age
group of 40 - 80 years from two large secondary care Scottish hospitals. Out of
which 144,066 patients who were treated for hypertension using angiotensin
antagonist, beta blockers, calcium channel blockers and thiazide diuretics
drugs were selected and compared with a control group of 111,936 patients who
did not use any of these drugs.
Sanjay Padmanaban M.D,
Ph.D., study author and professor at the University of Glasgow compared the
four classes of antihypertensive drugs along with the risk of mood disorders
and found that two drugs increased the risk of mood disorders while one of them
was found to decrease the risk.
He said that
"Mental health is under-recognized in hypertension clinical practice, and
the possible impact of antihypertensive drugs on mental health is an area that
physicians should be aware of and consider if the treatment of high blood
pressure is having a negative impact on their patient's mental health"
The findings of the
study reported that about 299 patients were admitted to the hospitals due to severe
depression. These patients were under high blood pressure treatment for an
average of 2.3 years.
Patients who took beta -
blockers or calcium channel blockers were at an increased risk for mood
disorders when compared to patients who were treated using angiotensin
On comparison with the
control group who did not take any drugs, patients who took angiotensin
antagonists had a lower risk for mood disorders. Thiazide diuretics were at the
same risk for mood disorders as that of the control group. It was also found
that presence of other medical conditions along with hypertension may also
influence the risk of mood disorders.
Padmanaban also said
that, "It is important that these results are validated in independent
studies. This is a single center study, which looked at the risk of the more
severe forms of mood disorders requiring hospitalization. It would be important
to study the effect of these drugs on minor to modest changes in mood, as these
will have an impact on the quality of life among hypertensive patients."
High Blood Pressure
The normal blood
pressure range for a healthy adult is 120/80 mm of Hg. High blood pressure
medications like beta - blockers, calcium channel blockers, angiotensin
antagonists and thiazide diuretics are some of the commonly prescribed drugs
for the treatment of hypertension.
Side Effects of Blood
- Beta-blockers - acebutolol, bisoprolol,
propranolol, metoprolol, labetalol
- Calcium channel
blockers - felodipine, amlodipine, diltiazem
receptor antagonists - losartan, valsartan, candesartan
converting enzyme inhibitors - enalapril, ramipril, lisinopril, fosinopril
diuretics - hydrochlorothiazide,
Common side effects of
blood pressure medicines may include:
- Dizziness or light
- Nausea and
- Erectile dysfunction
Mood disorders are
usually associated with distorted emotional state. Anxiety, depression, bipolar
disorders (This may vary from a feeling of extreme happiness or extreme
sadness) are few examples of mood related disorders.
Blood Pressure - General Information - (http://www.mayoclinic.org/diseases-conditions/high-blood-pressure/basics/definition/con-20019580)
- High Blood Pressure Fact Sheet - (http://www.cdc.gov/dhdsp/data_statistics/fact_sheets/fs_bloodpressure.htm)
- Hypertension in India - (http://www.cadiresearch.org/topic/hypertension/hypertension-india)
- High Blood Pressure Medicines - (https://medlineplus.gov/ency/article/007484.htm)