Bone fractures
can be very painful as it requires hospitalization and additional care that
would generally affect the quality of life of senior citizens.
that are caused due to osteoporosis could occur without any excessive physical
injury, even minor falls could lead to a fracture.
‘Injection of drug Abaloparatide found to decrease fracture risk for women with osteoporosis.’
Older people are often left worrying
about fractures and activities that involve a fair amount of physical exertion.
This stresses the need to find a preventive mechanism that safeguard older adults
from the risk of fractures.
Effect of
Abaloparatide on Lowering Fracture Risk among Osteoporotic Women
Dr Paul and
colleagues from the Colorado Center for Bone Research tested 2 different drugs
and a placebo on randomly selected women with osteoporosis. There were 3 groups
of study participants
- 824 women with osteoporosis
received injections of Abaloparatide
- 818 women with osteoporosis
received injections of Teriparatide
- 821 women with osteoporosis
received injections of Placebo
The study was
conducted across 10 countries and 28 sites with injections administered for 18
months. 2463 participated with an average age of 69 years were included in the
study and 1901 women completed the study.
New vertebral
fractures were seen in
- 0.58% in the Abaloparatide group.
- 0.84% in the Teriparatide group.
- 4.22% in the Placebo group.
Fractures other
than vertebra like hip or other bones that was estimated were
- 2.7% in the Abaloparatide group.
- 3.3% in the Teriparatide group.
- 4.7% in the Placebo group.
Other benefits
of using Abaloparatide were -
- Bone mineral density was found to
increase when compared with placebo
- The incidence of hypercalcemia was
lower in abaloparatide group than in teriparatide group.
The use of
abaloparatide shows a lot of promise in lowering the risk of fractures among
women with osteoporosis. However, the authors include a note of caution, "Further research is needed to understand the clinical
importance of risk difference, the risks and benefits of abaloparatide
treatment, and the efficacy of abaloparatide vs other osteoporosis
treatments."
References :- Osteoporosis - (https://medlineplus.gov/osteoporosis.html)
- What is Osteoporosis and What
Causes It? - (https://www.nof.org/patients/what-is-osteoporosis/)
- Injected drug
reduces risk of fracture among women with osteoporosis - (http://www.eurekalert.org/emb_releases/2016-08/tjnj-
idr081216.php)
Source: Medindia
