Celiac disease (CD) is a common systemic disorder related to gluten
intolerance and is often associated with different autoimmune and neurological
The study's lead author Dr. Luis Rodrigo of
University Hospital, Central Asturias, Spain and colleagues analyzed the
prevalence of serological, genetic, and histological disease markers in 72
multiple sclerosis patients and 126 of their first-degree relatives. Then the
results were compared with data from 123 healthy control subjects.
The results depicted seven MS patients (10%) with
positive screens for tissue IgA-anti-transglutaminase-2 antibodies, compared
with three positive screens for healthy controls (2.4%).
The team realized there is little difference in
HLA-DQ2 markers between MS patients (29%) and controls (26%) (NS). They found
eight MS patients (11.1%) with mild or moderate villous atrophy (Marsh III
type) in duodenal biopsies. Results also exhibited celiac disease in 26 of 126
first-degree relatives (32%).
Multiple Sclerosis patients displayed increased
frequency of circulating auto-antibodies such as anti-TPO in 19 (26%), ANA in
11 (15%) and AMA in 2 (3%).
Dr. Rodrigo commented, "We have found a prevalence of celiac
disease among MS patients that is 5 to 10 times higher compared with the
general population all over the world, which is between 1% and 2%."
He concluded by saying, "The increased prevalence of
celiac disease in MS patients and in their first-degree relatives suggests that
early detection and dietary treatment of celiac disease in antibody-positive MS
patients is advisable".