Antibiotic targeting gut bacteria may help treat autoimmune diseases, suggests new research.
The findings, published in the journal Science, showed that bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response.
Autoimmune Disorders
Autoimmune disorders occur when the immune system fails to recognize the body as 'self' and attacks it.
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‘Targeting gut bacteria with an antibiotic or vaccination may offer a promising new treatment approach for autoimmune diseases.’
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"Treatment with an antibiotic and other approaches such as vaccination are promising ways to improve the lives of patients with autoimmune disease," said senior study author Martin Kriegel from Yale University in New Haven, Connecticut, US.
Gut bacteria have been linked to a range of diseases, including autoimmune conditions characterised by immune system attack of healthy tissue.
To shed light on this link, the research team focused on Enterococcus gallinarum, a bacterium they discovered is able to spontaneously "translocate" outside of the gut to lymph nodes, the liver, and spleen.
![Quiz on Autoimmune Disorders]( "Quiz on Autoimmune Disorders")
The prevalence and incidence of autoimmune disorders such as type 1 diabetes, lupus and celiac disease are on the rise, revealed a study, however researchers at the Centers for Disease Control are unable to pinpoint a cause for this increase. Test your knowledge on autoimmune disorders by taking this quiz.
In models of genetically susceptible mice, the researchers observed that in tissues outside the gut, E. gallinarum initiated the production of auto-antibodies and inflammation -- hallmarks of the autoimmune response.
They confirmed the same mechanism of inflammation in cultured liver cells of healthy people, and the presence of this bacterium in livers of patients with autoimmune disease.
Through further experiments, the research team found that they could suppress autoimmunity in mice with an antibiotic or a vaccine aimed at E. gallinarum.
With either approach, the researchers were able to suppress growth of the bacterium in the tissues and blunt its effects on the immune system.
"When we blocked the pathway leading to inflammation, we could reverse the effect of this bug on autoimmunity," Kriegel said.
"The vaccine against E. gallinarum was a specific approach, as vaccinations against other bacteria we investigated did not prevent mortality and autoimmunity," he noted.
The vaccine was delivered through injection in muscle to avoid targeting other bacteria that reside in the gut.
The findings have relevance for systemic lupus and autoimmune liver disease, the researchers said.
Source: IANS
To shed light on this link, the research team focused on Enterococcus gallinarum, a bacterium they discovered is able to spontaneously "translocate" outside of the gut to lymph nodes, the liver, and spleen.
Quiz on Autoimmune Disorders
The prevalence and incidence of autoimmune disorders such as type 1 diabetes, lupus and celiac disease are on the rise, revealed a study, however researchers at the Centers for Disease Control are unable to pinpoint a cause for this increase. Test your knowledge on autoimmune disorders by taking this quiz.
Advertisement
In models of genetically susceptible mice, the researchers observed that in tissues outside the gut, E. gallinarum initiated the production of auto-antibodies and inflammation -- hallmarks of the autoimmune response.
They confirmed the same mechanism of inflammation in cultured liver cells of healthy people, and the presence of this bacterium in livers of patients with autoimmune disease.
Through further experiments, the research team found that they could suppress autoimmunity in mice with an antibiotic or a vaccine aimed at E. gallinarum.
With either approach, the researchers were able to suppress growth of the bacterium in the tissues and blunt its effects on the immune system.
"When we blocked the pathway leading to inflammation, we could reverse the effect of this bug on autoimmunity," Kriegel said.
"The vaccine against E. gallinarum was a specific approach, as vaccinations against other bacteria we investigated did not prevent mortality and autoimmunity," he noted.
The vaccine was delivered through injection in muscle to avoid targeting other bacteria that reside in the gut.
The findings have relevance for systemic lupus and autoimmune liver disease, the researchers said.
Source: IANS
Stress Can Trigger Allergies, Bowel Syndromes and Autoimmune Diseases
When the body is overworked, stress receptors signal the body to release chemical substances that cause allergies, irritable bowel syndrome.
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