The arthritic condition gout-treating drug colchicine could potentially reduce complications accompanying metabolic syndrome. According to the research published in Diabetes, Endocrinology, and Metabolism, a combination of high blood pressure, high blood sugar and other conditions that elevate the risk of heart disease and type 2 diabetes could significantly reduce by the action of the drug.
Previous studies have indicated that the system-wide inflammation that occurs in obesity plays a role in the development of type 2 diabetes. In the current study, researchers led by Jack A. Yanovski, M.D., Ph.D., of NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) randomly assigned 21 study participants to received colchicine twice a day for 3 months, while 19 participants received a placebo. Colchicine suppresses a multi-protein complex called NLRP3, which triggers the inflammation seen in obesity.
Gout
High levels of uric acid in blood and recurring attacks of joint inflammation are the main symptoms of gout. Lifestyle changes like weight loss, increasing fluid intake and dietary changes can help.
Researchers looked at several measures that reflect how well insulin works in the body to clear sugar from the blood (insulin resistance). There was no difference between the two groups in insulin resistance determined by one measure of insulin use (the frequently sampled, insulin-modified intravenous glucose tolerance test). However, the colchicine group showed improvement on the Homeostatic Model Assessment of Insulin Resistance test, which also estimates how much insulin is needed to keep blood sugar at a normal level while fasting. Those in the colchicine group also scored lower on a blood test of C-reactive protein and other tests that indicate inflammation. The authors concluded that larger studies are needed to determine if colchicine could prevent the development of type 2 diabetes in people with metabolic syndrome.
Source: Eurekalert
Gout and Diet
In gout excess of uric acid appears in the blood and its particles are deposited in joints as tophi.
 Diet, Nutrition and Supplements for Osteo-Arthritis and Rheumatoid ArthritisRheumatoid arthritis patients should consume a diet rich in natural antioxidant and anti-inflammatory nutrients and avoid foods like sugar, saturated fats, and trans fatty acids. | Advertisement
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Trigger Finger
Trigger finger is a condition in which a finger becomes bent and locked in an inward flexed (curved) position. It occurs due to inflammation of a tendon in the affected finger, resulting in severe pain and swelling.
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