by Dr. Meenakshy Varier on  September 24, 2016 at 4:40 PM Drug News
Gonorrhea Shows Increased Resistance To Antibiotics
A cluster of cases of gonorrhea in which the Neisseria gonorrhoeae bacteria showed high-level resistance to the last effective treatment has been reported by scientists from the Centers for Disease Control and Prevention and Hawaii's department of health.

The findings, presented at a conference on prevention of sexually transmitted diseases, represent the first cluster of cases in the United States that have shown such decreased susceptibility to the double-antibiotic combination used when other drugs have failed.

If the bacteria continue to develop resistance, that end-of-the-line therapy ultimately will fail, and an estimated 800,000 Americans a year could face untreatable gonorrhea and the serious health problems it cause.

In the United States, drug-resistant gonorrhea already is one of the country's three most urgent superbug threats, according to the Centers for Disease Control and Prevention.

CDC warned this summer that evidence of gonorrhea's diminished vulnerability to one of the last-resort drugs, azithromycin, was emerging nationwide. But it said the other antibiotic, ceftriaxone, was still effective.

There had already been signs that the bacteria, which have vanquished multiple other antibiotics, were starting to be able to evade azithromycin and cephalosporins, the class of antibiotics that includes ceftriaxone.

That is why the latest findings are so distressing for health officials. It means current treatment options are in jeopardy, said Gail Bolan, director of CDC's division of STD prevention. "What's unique about this cluster now identified in Hawaii is that these strains, we've really never seen before," she said.

Laboratory tests of the gonorrhea samples collected from seven people in Honolulu in April and May showed resistance to azithromycin at "dramatically higher levels" than typically seen in the United States, according to researchers from Hawaii's state health department. Five of the seven samples also showed increased resistance to ceftriaxone.

Since 2005, there have been four isolated cases reported in which the Neisseria gonorrhoeae bacteria had reduced susceptibility to both drugs. But this is the first time a cluster of such cases has been seen in the US.

"Our last line of defense against gonorrhea is weakening," Dr. Jonathan Mermin, director of CDC's National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention said in a statement.

The Hawaiian cases, six men and a woman, were all cured of their infections. But it seems only a matter of time before treatment failures occur.

Earlier this year doctors from Britain reported that a man infected with gonorrhea was not cured by his first course of antibiotics, though follow-up treatment three months later did quell the infection.

Many people don't actually know they're infected with gonorrhea because they have no symptoms. As a result, the disease goes undetected and untreated, which can cause a range of problems. Women risk chronic pelvic pain, life-threatening ectopic pregnancy and even infertility. And for both women and men, infection also increases the risk of contracting and transmitting HIV.

If this combination of drugs fail, there is no other treatment option currently available.

An oral antibiotic ETX0914, made by Entasis Therapeutics, of Waltham, Mass which is under development might offer a possible new treatment, researchers from Louisiana State University said at the CDC-sponsored conference in Atlanta. The drug was generally safe and effective in treating gonorrhea in a phase 2 clinical trial.

The experimental drug works differently from any currently marketed antibiotic. It is a single-dose oral therapy and could be used as an alternative to a ceftriaxone injection. In the randomized controlled trial, researchers treated 179 people with gonorrhea using the experimental drug alone (at two different dosages) or ceftriaxone alone. Virtually all the patients receiving the experimental drug were cured, they said. Every patient given ceftriaxone also was cured.

But it is still likely years away from hitting the market as those results will need to be confirmed in a large-scale clinical study.

Source: Medindia

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