Girls Born to Older Mothers Have Increased Breast Cancer Risk

Women born to mothers aged over 39 years and above have a higher risk of developing breast cancer, shows study.

These are the results of a new study that analyses the influence that certain birth and infancy characteristics have on mammographic density - an important indicator of breast cancer risk.

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Although the role that mammographic density plays in breast cancer has been known for years, researchers at the Carlos III Health Institute (ISCIII) have now headed a study that explores the influence of certain characteristics on mammographic density.

These include the proportion of white area on the mammogram, which is an important indicator of breast cancer risk.

The study was conducted on a sample of 3,574 women aged between 45 and 68 years. It was assisted by the screening programmes of seven of Spain's autonomous communities (Aragon, the Balearic Islands, Castilla-Leon, Catalonia, Galicia, Navarra and Valencia).

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The results reveal that women born to older mothers (above 39 years) and those who were taller and thinner than average before puberty are more prone to have a higher mammographic density as an adult.

Virginia Lope, lead author of the study and researcher at the National Centre for Epidemiology at the ISCIII, explains that "accumulated exposure to hormones along with growth factors in the earlier stages of life when the breasts begin to develop both condition breast tissue composition and influence the probability of developing a tumour as an adult."

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During the 2010 annual meeting of the American Association for Cancer Research (AACR), various studies were presented that support the results of other studies published a few years earlier. Such research showed that women with a mammographic density of 75 percent or above are five times more likely to develop breast cancer in comparison to women with a low density.

Furthermore, studies demonstrate that women who experience a reduction in breast density over six years are less at risk than those whose breast density remains stable.

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The study was published in the Breast Cancer Research and Treatment journal.

Source-ANI