About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

Genetically Engineered Life-Threatening Bacteria May Help Treat Cancer Safely

by Bidita Debnath on April 16, 2015 at 2:41 AM
Font : A-A+

Genetically Engineered Life-Threatening Bacteria May Help Treat Cancer Safely

Researchers test various modified lipopolysaccharide structure (LPS) of the Salmonella strain to see how they performed in test tube studies with human cancer cells and in tumour-bearing mice.

The investigational therapy has been found effective in test tube studies with human cancer cells and in tumor-bearing mice. Once it gets to human trials, the therapy would probably be used in conjunction with chemotherapy and radiation therapy, said Dr. Roy Curtiss, professor at Arizona State University and one of the researchers.

Advertisement

"There has long been interest in using genetically engineered microbes to target and destroy cells within solid tumors. I think this study goes a significant way in developing some strategies that will help in the overall means of using Salmonella as part of a cancer therapy," Curtiss noted.

In the new study, researchers focused on modifying the LPSof the Salmonella strain to make the bug less toxic. LPS, found in the outer membrane of bacteria, is one of the major inducers of sepsis, a life-threatening infection. The researchers used genetic engineering to delete genes involved in the synthesis of the LPS.
Advertisement

They identified a particular mutant strain that was the most effective at killing cancer cells and shrinking tumors, and also unable to cause disease. However, this mutant strain was less able to colonize the tumors, although being most effective in killing tumor cells when getting there.

To address this problem, the researchers then added another genetic modification that allowed the Salmonella to be injected in the mouse in a form that would not harm normal, healthy cells, was effective at colonizing tumors and, after entering cancer cells, would turn toxic.

The study was published in the journal mBio.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art MRSA - The Super Bug Food Safety for Health Antibiotics Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

Recommended Reading
Use of Muscle-building Pills, Powders Linked With Higher Risk of Testicular Cancer
The odds ratios increased to a 177% greater risk among younger men who used more than one kind of .....
D3 — New Smartphone Device Could Provide Rapid, Inexpensive Cancer Diagnosis
Digital diffraction diagnosis is clipped on to the camera and capable of recording data more than .....
Apples, Dietary Polyphenols in a Cup of Green Tea May Help Anti-Cancer Drugs
Researchers have found polyphenols in green tea and apples block a signalling molecule called VEGF, ...
Scientists Discover New Breath Technology To Predict Risk Of Stomach Cancer
A new breath test developed by scientists identifies high risk changes heralding stomach cancer ......
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general featu...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use