About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genetic Variations could be Responsible for Altered Drug Response

by Rishika Gupta on December 16, 2017 at 3:50 PM
Font : A-A+

Genetic Variations could be Responsible for Altered Drug Response

Genetic variations or differences in the genome have to be quantified to understand altered drug response of the population. The findings of this study are further discussed in Cell journal.

In a new study, they look at 108 G-protein-coupled receptors (GPCRs) in the human cell. These protein receptors are the main targets of the biggest group of marketed modern medicine.

Advertisement


By mining existing data sets, they have mapped the extent to which mutations occurred within GPCR drug targets in individuals and studied what impact these mutations could have on the therapeutic effect of medicine.

'We estimate that an average of 3 percent of the population have receptors that contain mutations which can alter the effect of medicine', says first author of the study, Ph.D. Fellow Alexander Hauser from the Department of Drug Design and Pharmacology at the University of Copenhagen.
Advertisement

'This might mean that the medicine simply works less efficiently. It can also mean that the medicine does not work at all or causes adverse effects on patients', adds Madan Babu, last author of the study, from the MRC Lab of Molecular Biology in Cambridge, where Hauser conducted this research.

The researchers have analyzed the mutations in human GPCRs by using whole genome sequencing data from the 1,000 Genomes project with about 2,500 participants as well as exome data from the ExAC project with over 60,000 participants.

They then used structural data to infer critical sites in GPCRs to uncover which mutations are more likely to alter the outcome of medicine.

'The 3 percent of the affected population is an average. For some important receptors, it is way more. For instance, the relevant mutations occur in 69 percent of people in the GLP1 receptor that is the target of diabetes medicine and in 86 percent of people in the CNR2 receptor that is used as a target for medicine to relieve nausea induced by chemotherapy. But of course, we cannot know every person's genome and so these are estimates based on the data sets available', says Alexander Hauser.

The researchers use their findings and sales data for the 279 GPCR-relevant drugs from the National Health Service in the UK to estimate how much money is spent on medicine with little or no effect.

As a conservative estimate, they find the economic burden on the UK National Health Service to be at least 14 million pounds annually, taking into account the number of people with mutations in both copies of the gene in important sites of the receptor target.

'The prevalence and potential impact of variation in drug response between individuals is a strong argument for further researching this field. It also constitutes a fine example of why personalized medicine might be the way forward; even when we are talking about common drugs', says Hauser.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Genetics and Stem Cells Signature Drug Toxicity Drugs Banned in India Christianson Syndrome 

Recommended Reading
Genetic Variation in Patients With Severe Vascular Complications of Infection
Major infections such as influenza and bacterial sepsis kill millions of people each year, often ......
Study Sheds Light on How Genetic Variations Affect Protein Function Among Humans
Researchers are hoping to shed light on how genetic variations between two human beings affect ......
Scientists Generate Largest Data Set of Cancer-Related Genetic Variations
At the National Cancer Institute (NCI), scientists have generated a data set of cancer-specific ......
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use