Genetic Variant Linked to Atrial Fibrillation Risk Identified

by Colleen Fleiss on April 11, 2018 at 2:18 AM

Association of a chromosomal genetic variant with increased risk of atrial fibrillation (AFib) in Latinos discovered by Darbar and his colleagues. The findings are reported in PLOS ONE.

"There is a paradox at play when it comes to atrial fibrillation in the Latino population," said Dr. Dawood Darbar. "While Latino individuals are less likely to develop atrial fibrillation than whites, despite having a higher burden of risk factors, they are more likely to suffer complications if the condition does develop," said Darbar, professor medicine and pharmacology in the University of Illinois at Chicago College of Medicine.

Atrial Fibrillation

Atrial fibrillation may not be life-threatening in itself but it is important to understand the causes, symptoms and treatments because of the risk of life-threatening complications.

‘Latino patients were found to be at a 2.3-fold increased risk for developing atrial fibrillation if they carried the common genetic variant, which is labeled rs10033464 SNP at chromosome 4q25.’

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Understanding this paradox has been a challenge because most research on the genetic basis of atrial fibrillation, or AFib, has been performed in whites of European descent. With the development of a large, diverse registry of patients with AFib, the most prevalent heart rhythm disorder worldwide, To identify common genetic variants, the researchers studied 713 patients who sought care at the University of Illinois Hospital in Chicago. The study group consisted of 103 Latino individuals who were prospectively enrolled in the UIC AFib Registry. Blood samples were analyzed for common genetic variants at a number of chromosomal locations and compared with genetic analysis results of 610 individuals without AFib.

"Our goal was to determine if the top nine gene variants known to be associated with AFib in white patients also increase susceptibility in Latinos," said Darbar, who is chief of cardiology. "We found that one variant was also prevalent in Latinos with AFib, particularly those from Mexico," Darbar said, "and that its predictive effect was stronger in Latinos than in whites." Darbar says this finding not only sheds light on the underlying mechanisms of AFib, but it also, and more importantly, helps advance prevention and treatment strategies for AFib in Latinos. "The presence of an AFib-associated genetic variant helps doctors personalize treatment for the individual patient," Darbar said. This is key, he says, to preventing complications, the most serious and common of which is stroke, which in some cases can lead to lifelong disability or death.

"It also alerts us to a possible familial link that can help identify when family members may also be at risk," Darbar said.

Source: Eurekalert

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