Gene therapy that can induce heart cells to regenerate after a heart attack has been developed by researchers from King's College London.
Myocardial infarction, more commonly known as a heart attack, caused by the sudden blocking of one of the cardiac coronary arteries, is the main cause of heart failure, a condition that now affects over 23 million population in the world, according to the World Health Organisation.
At present, when a patient survives a heart attack, they are left with permanent structural damage to their heart through the formation of a scar, which can lead to heart failure in the future. In contrast to fish and salamander, which can regenerate the heart throughout life.
Heart Attack- Lifestyle risks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed.
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‘Cardiac regeneration can be achieved by administering an effective genetic drug that stimulates cardiac regeneration in a large animal, with heart anatomy and physiology like that of humans.’
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In this study, published today in Nature, the team of investigators delivered a small piece of genetic material, called microRNA-199, to the heart of pigs, after a myocardial infarction which resulted in the almost complete recovery of cardiac function at one month later.
Lead author Professor Mauro Giacca, from King's College London said: "It is a very exciting moment for the field. After so many unsuccessful attempts at regenerating the heart using stem cells, which all have failed so far, for the first time we see real cardiac repair in a large animal."
"It will take some time before we can proceed to clinical trials" explained Professor Giacca. "We still need to learn how to administer the RNA as a synthetic molecule in large animals and then in patients, but we already know this works well in mice".
Source: Eurekalert
"It will take some time before we can proceed to clinical trials" explained Professor Giacca. "We still need to learn how to administer the RNA as a synthetic molecule in large animals and then in patients, but we already know this works well in mice".
Source: Eurekalert
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.
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 Quiz on Heart AttackThe risk factors that work behind the scene before a heart attack are familiar to many. But do you realize the extent to which your lifestyle choices are putting your life at risk? Can you identify a heart attack when it occurs? Take our quiz and find out. | Advertisement
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