About My Health Careers Internship MedBlogs Contact us

Genetic Predictors That may Lead to Oesophageal Cancer Identified

by VR Sreeraman on November 6, 2008 at 6:03 PM
Font : A-A+

 Genetic Predictors That may Lead to Oesophageal Cancer Identified

Scientists at the University of Texas M. D. Anderson Cancer Center have identified 11 genotypes that may elevate the risk for oesophageal cancer.

Some of the major risk factors associated with oesophageal cancer include obesity, smoking and gastro-oesophageal reflux disease.


While the risk factors are quite prevalent in the general population, the incidence rate of esophageal cancer is quite low, which means that only a small percentage of people are genetically predisposed to develop oesophageal cancer.

The researchers have identified 11 single-nucleotide polymorphisms (SNPs) in microRNA-related genes that showed at least a borderline significant association with oesophageal cancer.

A person can have one or more of these SNPs in their genetic makeup, putting him or her into low-risk, medium-risk and high-risk groups.

"We observed a significantly increased risk of oesophageal cancer with increasing numbers of risk genotypes," said Yuanqing Ye, Ph.D., an instructor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center.

In the study, it was found that each unfavourable genotype was associated with an increased cancer risk. Individuals with more than four unfavourable genotypes were more than three times as likely to develop oesophageal cancer.

"Our ultimate goal is to construct a quantitative cancer risk prediction model based on an individual's epidemiological profile, environment exposure and genetic makeup. This risk prediction model can evaluate each person's relative risk and absolute risk of developing oesophageal cancer within a certain time period," said Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center and lead author of the study.

Usually, most of the oesophageal cancer patients are diagnosed at an advanced stage with poor prognosis.

The knowledge of what places a person at high risk for oesophageal cancer may have clinical applications to guide cancer screening, intensive monitoring, and cancer prevention.

"Considering the dramatic increase in incidence, difficulty of early diagnosis, the poor survival rate for esophageal cancer, and the limited knowledge of the natural history of this tumor, we need a greater understanding of the etiology of esophageal cancer for improvement of diagnosis and hopefully a better prognosis," said Wu.

The study was published in the latest issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

Source: ANI

News A-Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Genetics and Stem Cells Cancer Facts Cancer Christianson Syndrome Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Reflux Esophagitis
Reflux esophagitis is a condition causing inflammation of the lining of the esophagus. This happens ...
This condition occurs due to the reflux of hydrochloric acid of the stomach into the oesophagus...
Obese People are at Increased Risk of Developing Cancer: Study
Overweight people are at a significantly higher risk of developing a range of common cancers, ......
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use