Several genetic markers that could help identify individuals at risk for developing acute kidney injury in the hospital setting have been discovered by researchers. The new research will be presented at ASN Kidney Week 2014. Utilizing new genetic analysis techniques, scientists pinpointed several markers associated with AKI-an increasingly prevalent surgical and hospital complication.
Collaborators from Yale University, Vanderbilt University, and the University of Western Ontario wanted to determine if they could identify patients who may have a higher genetic risk for develop AKI in the hospital. "This may uncover novel pathways to target for therapeutic interventions," said senior author Chirag R. Parikh, MD, PhD, FASN of Yale.
Kidney Failure due to Melamine Toxicity
Adulteration of food with melamine results in the formation of kidney stones and kidney failure, even leading to death.
Advertisement
Until recently, analysis methods limited the scope of genetic AKI studies. "But technological progress in genotyping has opened the possibilities towards hypothesis-generating genomic screens and novel opportunities to explore polygenetic perspectives, now spanning a wide array of possible analyses falling under the term Genome-Wide Association Study (GWAS)," said Dr. Parikh.
Using GWAS methods, the investigators analyzed data from patients at risk for AKI in the hospital setting-760 adults with AKI and 669 controls who underwent surgery or received care in the ICU-to determine if any single nucleotide polymorphisms (SNPs) were linked to AKI development. They identified 6 clusters of 3 or more SNPs on 6 different chromosomes that are associated with a patient's risk of developing AKI.
![Interesting Facts about Urinary System]( "Interesting Facts about Urinary System")
The Urinary System helps in eliminating the waste products from our body and maintains the acid base and fluid balance of the body. Read more for interesting facts about urinary system.
"AKI is heterogenous disease and genetic studies need to be continued to fully capture the host risk," Dr. Parikh emphasized. "It is recommended that sequencing can be used as a complement to GWAS, to obtain a better map of the genetic variants in GWAS-significant genes or well-established candidate genes."
This study was supported by the National Institutes of Health NIH R01HL085757 and P30 DK079310 O'Brien Kidney Center Grant.
Study: "A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Conferring Risk for Acute Kidney Injury" (Abstract TH-OR028)
Disclosure information is available at
http://www.asn-online.org/education/kidneyweek/2014/program-faculty.aspx.
ASN Kidney Week 2014, the largest nephrology meeting of its kind, will provide a forum for more than 13,000 professionals to discuss the latest findings in kidney health research and engage in educational sessions related to advances in the care of patients with kidney and related disorders.
ASN Kidney Week 2014 will take place November 11-16, 2014, at the Pennsylvania Convention Center in Philadelphia, PA.
ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Founded in 1966, and with nearly 15,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.
Source: Newswise
Interesting Facts about Urinary System
The Urinary System helps in eliminating the waste products from our body and maintains the acid base and fluid balance of the body. Read more for interesting facts about urinary system.
Advertisement
"AKI is heterogenous disease and genetic studies need to be continued to fully capture the host risk," Dr. Parikh emphasized. "It is recommended that sequencing can be used as a complement to GWAS, to obtain a better map of the genetic variants in GWAS-significant genes or well-established candidate genes."
This study was supported by the National Institutes of Health NIH R01HL085757 and P30 DK079310 O'Brien Kidney Center Grant.
Study: "A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Conferring Risk for Acute Kidney Injury" (Abstract TH-OR028)
Disclosure information is available at
http://www.asn-online.org/education/kidneyweek/2014/program-faculty.aspx.
ASN Kidney Week 2014, the largest nephrology meeting of its kind, will provide a forum for more than 13,000 professionals to discuss the latest findings in kidney health research and engage in educational sessions related to advances in the care of patients with kidney and related disorders.
ASN Kidney Week 2014 will take place November 11-16, 2014, at the Pennsylvania Convention Center in Philadelphia, PA.
ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Founded in 1966, and with nearly 15,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.
Source: Newswise
Protein Catabolic Rate
Find out breakdown rate of proteins in patients suffering from kidney problem and for those undergoing dialysis.
Advertisement
 Quiz on KidneyThe kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine. Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The | Advertisement
|
Advertisement
Recommended Reading
Latest Research News
Brain plasticity following blindness leads to superior ability in sensing signals from the heart, which has implications for bodily awareness and emotional processing.
A group of scientists were awarded £1.3 million to create a new “point of care testing” kit that detects Alzheimer's disease biomarkers.
Is there a connection between Osteoporosis and dementia? Yes, loss in bone density may be linked to an increased risk of dementia in older age.
Link between chromosome length and biological aging marker discovered. The finding helps explain why people with longer telomeres have a lower dementia risk.
Integrated structural biology helps discover how the cystic fibrosis transmembrane conductance regulator (CFTR) works.