Collaborators from Yale University, Vanderbilt University, and the University of Western Ontario wanted to determine if they could identify patients who may have a higher genetic risk for develop AKI in the hospital. "This may uncover novel pathways to target for therapeutic interventions," said senior author Chirag R. Parikh, MD, PhD, FASN of Yale.
Until recently, analysis methods limited the scope of genetic AKI studies. "But technological progress in genotyping has opened the possibilities towards hypothesis-generating genomic screens and novel opportunities to explore polygenetic perspectives, now spanning a wide array of possible analyses falling under the term Genome-Wide Association Study (GWAS)," said Dr. Parikh.
"AKI is heterogenous disease and genetic studies need to be continued to fully capture the host risk," Dr. Parikh emphasized. "It is recommended that sequencing can be used as a complement to GWAS, to obtain a better map of the genetic variants in GWAS-significant genes or well-established candidate genes."
This study was supported by the National Institutes of Health NIH R01HL085757 and P30 DK079310 O'Brien Kidney Center Grant.
Study: "A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Conferring Risk for Acute Kidney Injury" (Abstract TH-OR028)
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