About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genetic Markers Help Predict Osteoporotic Fracture Risk

by Iswarya on July 21, 2020 at 3:47 PM
Font : A-A+

Genetic Markers Help Predict Osteoporotic Fracture Risk

Genetic pre-screening could decrease the number of screening tests needed to identify individuals at risk for osteoporotic fractures, reports a new study. The findings of the study are published in the journal PLOS Medicine.

Fractures, which lead to significant morbidity, mortality, and expense, are a large public health concern. Annual costs associated with fractures exceed $19 billion in the United States.

Advertisement


Dual-energy X-ray absorptiometry (DXA), which measures bone mineral density (BMD), has been considered the clinical standard for determining fracture risk, along with the Fracture Risk Assessment Tool (FRAX). A FRAX assessment considers factors such as age, gender, weight, alcohol use, smoking history, and fracture history. Screening programs are generally designed to identify those whose risk is great enough to require intervention. However, the assessment takes time, and DXA accessibility has declined. Usually, only a small proportion of individuals who undergo screening is found to be at high risk, indicating that much of the screening expenditure is spent on individuals who will not qualify for treatment.

The potential exists to improve the efficiency of osteoporosis screening programs using genetic markers to assess fracture risk. This study aimed to understand if genetic pre-screening could reduce the number of screening tests needed to identify individuals at risk of osteoporotic fractures. It used genetic data from more than 300,000 participants from the UK Biobank to calculate the genetically predicted bone ultrasound measure. This was then compared with the commonly used FRAX score and standard BMD measured by DXA as to its ability to predict the risk for fracture.
Advertisement

By building a polygenic risk score and validating its utility in fracture risk screening in five separate cohorts totaling more than 10,000 individuals, study researchers determined that genomics-enabled fracture risk screening could reduce the proportion of people who require BMD-based testing by 41 percent while maintaining a high ability to correctly determine the appropriate treatment for those at risk. While these findings are not meant to be prescriptive, they indicate the possible utility of polygenic risk scores in screening programs that are dependent on heritable risk factors.

"Someday, everyone will know their genetic predispositions to various diseases and traits because genetic typing has become so inexpensive," said Dr. Kiel.

"When available, these genetic markers can be used to predict diseases to help health care providers screen and treat patients tailored to their genetic predisposition to a given disease. Using genetic risk scores to guide screening for osteoporosis may result in disease screening strategies that are more thoughtful and personalized than the one-size-fits-all approach currently in place within medical practice."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Fracture Fracture of Knee Cap Genetics and Stem Cells Colle’s Fracture Fracture Neck of Femur Screening for Osteoporosis Injuries Related to Sports Christianson Syndrome Scaphoid Fracture of The Wrist Stress Fracture 

Recommended Reading
Screening for Osteoporosis
The risk of suffering from osteoporotic fractures is 30-50% in women and 15 to 30% in men. ......
Lifestyle And Osteoporosis
Encyclopedia section of medindia briefly explains about Lifestyle and Osteoporosis...
Osteoporosis
Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is ......
World Osteoporosis Day: Focus on ‘Emotional Aspects’
World Osteoporosis Day is celebrated on 20th October every year. It aims to create global awareness ...
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Colle’s Fracture
Colles fracture or broken wrist is a wrist fracture, which occurs within an inch of the wrist joint....
Fracture
A fracture is a condition where the continuity of the bone is lost. Majority of bone fractures occur...
Fracture of Knee Cap
Patella fracture is a kneecap injury that needs surgical correction. Undisplaced fracture can be hea...
Injuries Related to Sports
Injuries are common in the sporting world. They can be minor like bruises and cuts, serious like fra...
Scaphoid Fracture of The Wrist
The scaphoid is a small wrist bone. Scaphoid bone fractures usually occur when a person falls heavil...
Stress Fracture
Stress fractures are small fractures which often occur in the weight bearing bones of the lower leg ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)