Specific genes associated with a rare liver disease has been identified by scientists. The large-scale genetic study defines the relationship between primary sclerosing cholangitis and other autoimmune diseases. Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16. Approximately 70 percent of people who suffer from PSC also suffer from IBD. The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD). For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease. PSC is a chronic, progressive disease of the bile ducts that channels bile from the liver into the intestines. It can cause inflammation of the bile ducts (cholangitis) and liver scarring that leads to liver cirrhosis and liver failure. There are no effective treatments available. Although PSC affects only one in 10,000 people, it is a leading cause of liver transplant surgery, reports Science Daily. "Before our study, it was never quite clear whether PSC was a complication of IBD or a distinct disease in its own right," says Carl Anderson, lead author from the Wellcome Trust Sanger Institute, a genome research institute. "We have proven it to be a unique disease, and hope that our results will inform the development of more effective treatments, designed to target the biological pathways involved in causing the disease".Source: IANS << Scientists Create Biggest Family Tree of Human Cells Hemophilia Awareness Rally Held in Capital >> Recommended Reading Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Quiz on Liver How many of us know that the liver is a vital organ the size of an American Football? To understand more about the liver and its functions spend a few minutes taking part in this ... READ MORE Liver Cancer - Animation Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it's symptoms are presented in this ... READ MORE Paving Way for Long-sought Treatments for Liver Disease Is A New Genetic Screen One million deaths around the world each year are caused due to chronic liver failure which happens to be a major health problem. READ MORE Christianson Syndrome Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC9A6 that is present on X chromosome. It primarily affects the nervous system. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Loss of Taste Symptom of loss of taste usually occurs in combination with loss of smell and can be complete loss or partial loss of taste. It can also be temporary or permanent, though the latter is very rare. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Diaphragmatic Hernia Selfie Addiction Calculator Nutam (400mg) (Piracetam) More News on: Hepatitis AGenetics and Stem CellsLiverWilson's DiseaseChristianson SyndromeMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLoss of TasteLiving Donor Liver Transplant: What Are the Risks?