The University of Nottingham's Professor John Armour and Dr Angus Davison, in collaboration with UCL's Professor Chris McManus, conducted a twin study examining the whole genome - which contains hereditary information - of nearly 4,000 subjects from the London Twin Research Unit to compare left and right handed participants.
The study was unable to find a strong genetic factor in determining handedness.
If there was a single major genetic determination of handedness, there should be a detectable shift between left and right handed people in the frequency of variants in that part of the genome - and this isn't the case.
Professor Armour, Professor of Human Genetics at The University of Nottingham, said that there should be a detectable shift between right and left handed people because modern methods for typing genetic variation cover nearly all of the genome.
The study has been published in the journal Heredity.