About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genetic Drivers of Lymphoma Identified

by Hannah Joy on October 7, 2017 at 2:36 PM
Font : A-A+

Genetic Drivers of Lymphoma Identified

Lymphoma, the most common blood cancer lacks better diagnosis and treatment facilities due to lack of information on genetics for this disease, reveals a new study.

An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer diffuse large B cell lymphoma and how those genes might play a role in patients' responses to therapies.

Advertisement


The researchers analyzed tumor samples from 1,001 patients who had been diagnosed with diffuse large B cell lymphoma over the past decade. These patients had been treated at 12 institutions around the world.

Using whole exome sequencing, the researchers pinpointed 150 genetic drivers of the disease, many newly identified.

The team then tested to see if there were any correlations between the genes and how well patients had responded to standard therapies.
Advertisement

The team applied a genome editing technique known as CRISPR to knock out each of thel 20,000 genes in lymphoma cells to identify those that are critical for lymphoma cells to grow.

By assessing the genetic, CRISPR and clinical results, the researchers found several critical genetic links that could help guide treatments. These findings published online in the journal Cell.

"This work provides a comprehensive road map in terms of research and clinical priorities," said Sandeep Davé, M.D., professor of medicine at Duke.

"We have very good data now to pursue new and existing therapies that might target the genetic mutations we identified. Additionally, this data could also be used to develop genetic markers that steer patients to therapies that would be most effective."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetics and Stem Cells Chronic Lymphocytic Leukemia AIDS-HIV-Cancer Bone Marrow Transplantation Christianson Syndrome 

Recommended Reading
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by ....
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
AIDS-HIV-Cancer
AIDS defining malignancies are cancers that occur in patients with AIDS due to their low immunity....
Burkitt’s Lymphoma
Burkitt's lymphoma is a rare type of non-hodgkin's lymphoma that commonly affects children. It ......
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Christianson Syndrome
Christianson syndrome is a condition that occurs due to mutations (abnormal changes) in the gene SLC...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use