Researchers worked on a series of genetic analysis and identified genetic differences in normal breast tissue among several racial groups.
Scientists from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has been working for quite some time on the hypothesis that there are underlying genetic differences in breast tissue across ethnicities, which would explain, at least in part, disparities in morbidity and mortality," said Baumbach.
Baumbach's research group is observing a multi-ethnic cohort of patients with triple-negative breast cancer, including 10 blacks, 10 Hispanics and 10 non-Hispanic whites. Study samples were marked by pathology as normal vs. tumor tissue. They were then analyzed for RNA isolation, cDNA preparation and hybridization of tumor/normal cDNAs and compared to a breast cancer focused gene expression array.