About Careers Internship MedBlog Contact us

Genetic Analysis in Kindergarteners to Prevent Behavioral Problems

by Julia Samuel on January 8, 2015 at 3:13 PM
Genetic Analysis in Kindergarteners to Prevent Behavioral Problems

Behavioural problems in children is addressed by early intervention. Identifying sources of variation in intervention effects can suggest means to improve efficiency.

Psychopathology is the study of mental illness or mental distress or the manifestation of behaviours and experiences, which indicates mental illness or psychological impairment.


Genome is one potential source of such variation. The fast track randomised control trial, 10 year long intervention period, conducted genetic analysis to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior.

Tests were conducted to associate variants of the glucocorticoid receptor gene NR3C1 with differences in response to the Fast Track intervention.

Glucocorticoid receptors, regulates genes controlling the development, metabolism, and immune response and has various effects in different parts of the body. It functions as a major component of endocrine influence - specifically the stress response upon the brain.

A variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in European-American children belonging to the control group and decreased risk for externalizing psychopathology in intervention group.

There was no association between variation in NR3C1 and differential intervention response in African-American children.

Source: Medindia
Font : A-A+



Recommended Readings

Latest Child Health News

Amblyopia or Poor Vision in Kids - Does Digital Vision Training Help?
Children with amblyopia or lazy eye who underwent digital vision training, showed no appreciable improvement in their eyesight.
Childhood Malnutrition Linked to Stunted Growth and Mortality Risk
In 2022, over 20% of children worldwide lacked adequate calories for growth, with 45+ million showing wasting (underweight for height).
Pneumococcal Vaccines Reduce Severe Infections in Kids With Sickle Cell Disease
After PCV7 licensure, pneumococcal infection rates in children aged 5+ with sickle cell disease significantly decreased.
Breast Milk Proteins to Boost Baby's Gut Health
Breast milk concentration of certain key proteins indicates abundance of healthy bacteria in babies' guts.
Urban Life Fuels Risk of  Respiratory Illness in Children
Compared to young children who grow up in rural areas, city kids are more prone to suffer respiratory infections due to environmental factors.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Genetic Analysis in Kindergarteners to Prevent Behavioral Problems Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests