About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genes That Influence Parkinson's Onset Identified

by Tanya Thomas on October 11, 2009 at 12:12 PM
Font : A-A+

 Genes That Influence Parkinson's Onset Identified

Researchers from Boston University School of Medicine (BUSM) report that the genes, which may influence the onset age of Parkinson's Disease (PD) have been identified.

The findings are the first to identify genes contributing to the variation in onset age and may help identify mechanisms and therapeutic targets capable of delaying symptoms.

Advertisement

PD is the second most common neurodegenerative disorder usually occurring late in life and is characterized by debilitating symptoms of tremor, rigidity, and slowed ability to start and continue movements.

The BUSM researchers performed analyses using genotypes generated with the Illumina HumanCNV370Duo array in a sample of 857 unrelated, familial PD cases.
Advertisement

Then, they performed a meta-analysis of imputed Single Nucleotide polymorphisms (SNPs) by combining the familial PD data with that from a previous genome-wide associated study (GWAS) of 440 idiopathic PD cases.

And they identified the 15q26.2 region as well as the gene AAK1 related to the previously observed PD susceptibility gene, GAK as areas that would benefit from further examination.

"Important distinctions can be made between those genes that influence susceptibility for developing disease, and the genetic modifiers that influence onset age," said joint lead author Dr. Jeanne C. Latourelle, from the department of neurology at BUSM.

Latourelle said that the findings highlight the importance of continuing the study of onset age of PD that could provide insight into the disease mechanisms and processes for delaying onset with implications for novel treatments.

The study has been published in BMC Medical Genetics.

Source: ANI
TAN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Weaver Syndrome Nutritional Management of Parkinsons disease 

Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Trials to Test Gene Therapy for Parkinson's Disease Underway
Scientists at Michigan hospital have launched a trial to test gene transfer therapy that would help ...
Risk of Crashes in Low Visibility High in Drivers With Parkinson's Disease
New research has revealed that drivers with mild to moderate Parkinson's disease may be at higher .....
Drug Rasagiline may Slow Parkinson's Progression
Scientists from Mount Sinai School of Medicine have found that drug rasagiline not only helps treat ...
Nutritional Management of Parkinsons disease
Parkinson's disease is a brain disorder which leads to many other related effects. Nutrition plays a...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use