Scientists have discovered a gene variant that helps predict the amount of weight loss after gastric bypass surgery.
The findings explain why the success of gastric bypass surgery varies so widely and could help clinicians identify those who would benefit the most from this type of surgery.
Bariatric Surgery
Bariatric surgery is the most effective weight-loss therapy for the morbidly obese. Lap banding and gastric bypass are the most commonly used weight loss surgeries.
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"Surgery is the most effective therapy for severe obesity, but these procedures are invasive, and not all patients get the same degree of benefit," senior study author Lee Kaplan of Massachusetts General Hospital and Harvard Medical School said.
"If we can identify those patients who are likely to lose more weight after surgery from those who do less well, we could help steer patients towards the therapy that best suits them," Kaplan said.
![Quiz on Weight Loss]( "Quiz on Weight Loss")
If you thought fried foods, processed foods and potato are the bad guys in your weight loss plan, you thought right! Take this quiz and find out what actually can help you get the figure you always wanted.
Individuals who undergo gastric bypass surgery lose on average about 35 percent to 40 percent of their initial weight and keep most of this weight off.
But the amount of weight lost by different patients varies by a factor of four, and it is not understood what causes this wide difference in response.
To identify specific genetic factors that might play a role, Kaplan and his team examined the genomes of more than 1,000 individuals undergoing gastric bypass surgery.
They found that individuals with two copies of a specific variant on chromosome 15 lost on average about 39 percent of their body weight, whereas those without a copy of this variant lost less than 30 percent of their body weight.
Moreover, the activity of the gene located closest to this variant also predicted weight loss.
The study is published in The American Journal of Human Genetics.
Source: ANI
Quiz on Weight Loss
If you thought fried foods, processed foods and potato are the bad guys in your weight loss plan, you thought right! Take this quiz and find out what actually can help you get the figure you always wanted.
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Individuals who undergo gastric bypass surgery lose on average about 35 percent to 40 percent of their initial weight and keep most of this weight off.
But the amount of weight lost by different patients varies by a factor of four, and it is not understood what causes this wide difference in response.
To identify specific genetic factors that might play a role, Kaplan and his team examined the genomes of more than 1,000 individuals undergoing gastric bypass surgery.
They found that individuals with two copies of a specific variant on chromosome 15 lost on average about 39 percent of their body weight, whereas those without a copy of this variant lost less than 30 percent of their body weight.
Moreover, the activity of the gene located closest to this variant also predicted weight loss.
The study is published in The American Journal of Human Genetics.
Source: ANI
Weight Loss Surgery may Affect Genes too
Gastric bypass surgery is efficient at reducing the body weight of individuals in a very short span.
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 Following Weight Loss Surgery, Women Should Wait at Least 12 Months Before Trying for a BabyA new evidence-based literature review suggests that women should wait at least 12 months before trying for a baby following weight loss surgery. | Advertisement
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