About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genes may Cause Digestive Disorder in Infants

by Kathy Jones on June 17, 2010 at 9:59 PM
Font : A-A+

 Genes may Cause Digestive Disorder in Infants

A new study says that digestive tract disorder pyloric stenosis is more prevalent among twins and siblings, indicating that this is a genetic and inherited disorder.

The study was conducted on nearly 2 million children born in Denmark.

Advertisement

Pyloric stenosis is a severe and potentially fatal condition in which apparently healthy in-fants, typically 2 to 8 weeks old, develop an inability to pass food from the stomach into the duodenum (part of the small intestine).

"Today pyloric stenosis is the most common condition requir-ing surgery in the first months of life. Among white individuals, pyloric ste-nosis is relatively common, with an incidence of 1.5 to 3 per 1000 live births," wrote the authors.
Advertisement

"Case reports have suggested familial aggregation [the occurrence of more cases of a given disorder in close relatives of a person with the disorder than in control families], but to what extent this is caused by common environment or inheritance is unknown," he added.

Dr. Camilla Krogh, of the Statens Serum Insti-tut, Copenhagen, Denmark, and colleagues examined the familial aggregation of py-loric stenosis from monozygotic twins (derived from a single fertilized egg) to fourth-generation relatives in the population of Denmark.

The population-based cohort study included 1,999,738 chil-dren born in Denmark between 1977 and 2008 and followed up for the first year of life, during which 3,362 children had surgery for pyloric stenosis.

Among the findings of the researchers, 46 percent of children with an affected monozygotic twin were diagnosed as having pyloric stenosis.

In dizygotic twins (derived from two separately fertilized eggs), 7.7 percent with an affected twin had py-loric stenosis.

"This nationwide study documented strong familial aggregation of pyloric stenosis, with a nearly 200-fold in-crease among monozygotic twins and 20-fold increase among siblings. Fa-milial aggregation of pyloric stenosis was pronounced even in more distant relatives," wrote the authors.

"Our findings argue for a hereditary component of pyloric stenosis: (1) pre-dominance in boys; (2) familial aggre-gation in first-, second-, and third-degree relatives; (3) high concordance rate in monozygotic twins; (4) similar degree of aggregation in dizygotic twins and siblings; (5) difference in risk for siblings vs. maternal half-siblings (as well as cousins vs. half-cousins); and (6) heritability of 87 percent."

"... with a heritability esti-mate of 87 percent, it seems that familial ag-gregation is primarily explained by shared genes that may affect re-sponses to postnatal factors. The high rates for twins and siblings should be considered in counseling families with affected children," concluded the researchers.

The study was published in the latest issue of JAMA.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Ulcerative Colitis Wonder Herbs for those Digestion Blues Weaver Syndrome Digestive Myths Loss of Taste Travelerīs Diarrhea Dumping Syndrome Gastroparesis 

Recommended Reading
Genetic Counseling
Encyclopedia section of medindia gives general info about Genetic counseling ...
Epigenetics
In the recent years 'epigenetics' represents inheritable changes in gene expression that do not ......
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex ......
Dumping Syndrome
Dumping syndrome is the set of symptoms seen when largely undigested food from the stomach moves rap...
Gastroparesis
Gastroparesis is a digestive disorder in which your stomach muscles and nerves are weakened causing ...
Loss of Taste
Symptom of loss of taste usually occurs in combination with loss of smell and can be complete loss o...
Travelerīs Diarrhea
Traveler’s diarrhea is a digestive disorder transmitted through contaminated food and water which ca...
Ulcerative Colitis
Ulcerative colitis is characterized by bouts of diarrhea, bleeding per rectum and pain, which remits...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...
Wonder Herbs for those Digestion Blues
Traditional Ayurvedic literature emphasizes the importance of good digestion. Good digestion is pref...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use