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Genes Act as Umpire in the Body's Fight Against Cancer

by Rathi Manohar on July 15, 2010 at 5:51 PM
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Genes Act as Umpire in the Body's Fight Against Cancer

Mahjong and Lgl, two genes, decide on the fight between the body's own cells and cancer cells, disclosed a Medical Research Council (MRC) study.

This discovery could lead to future treatments to make our healthy cells better equipped to attack cancer cells, an entirely new concept for cancer research.

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The team, who undertook the research at the MRC Laboratory for Molecular Cell Biology and Cell Biology Unit at University College London (UCL), have proven that normal cells and cancerous cells compete in a game of 'do or die'.

If non-cancerous cells gain the advantage and entirely surround cancer cells, the cancer cells will die.

However, if the cancerous cells manage to break free, they will continue to divide and grow undisturbed.
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The study shows that the Lgl and Mahjong proteins play a key role in the cells' competitiveness, influencing the outcome over which cells will die.

This kind of cell competition had previously been shown to occur in flies, however this is the first time it has been seen in mammals.

The discovery could potentially lead to new kinds of treatments for carcinomas, tumours which make up more than 80 per cent of all cancers.

Carcinomas originate from the epithelial cells that make up tissues such as our lungs, glands and digestive system.

"This is the first time that we have seen cancer cells being killed simply by being surrounded by healthy cells. If we can build on this knowledge and improve our understanding of how this happens, in the future we may be able to find a way to enhance this ability and develop a totally new way of preventing and treating cancer," said Dr Yasuyuki Fujita.

The study has been published in the online, open-access journal PLoS Biology.

Source: ANI
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