About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Generating Thyroid Cells to Develop New Therapies for Thyroid Disorders

by Madhumathi Palaniappan on February 6, 2017 at 10:09 AM
Font : A-A+

Generating Thyroid Cells to Develop New Therapies for Thyroid Disorders

A new way to generate thyroid cells known as thyrocytes using genetically modified embryonic stem cells was recently discovered by a research team from the Boston University School of Medicine (BUSM).

The findings, which appear in the journal Stem Cell Reports, are the first step to developing a similar protocol using human stem cells that will allow the modeling of thyroid disease to better understand its causes and the development of therapies.

Advertisement


Thyroid disorders affect approximately 10 percent of the U.S. population and include Grave's disease or Hashimoto's disease, which can result in hyper or hypothyroidism, thyroid nodules, goiter or cancer.

Researchers from Boston University School of Medicine (BUSM), engineered mouse embryonic stem cells cultured in the lab to express a genetic switch for a specific gene, Nkx2-1, that is important for thyroid development. Then they guided the embryonic stem cells through various stages while switching Nkx2-1 on and off for short periods of time and found there was one narrow timeframe where turning on this gene converted the majority of cells to thyroid cells.
Advertisement

"This method resulted in high yield of our target cell type, thyroid cells, but it may be applicable for the derivation of other clinically relevant cell types such as lung cells, insulin-producing cells, liver cells, etc.," explained Laertis Ikonomou, PhD, assistant professor of medicine at BUSM and member of the Center for Regenerative Medicine (CReM) at Boston Medical Center and BUSM.

The researchers hope this study will lead to the development of therapeutics or stem cell/genetic engineering technologies that will improve the quality of life for the many people afflicted with thyroid and other disorders.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Iodine Deficiency Disorder Hyperthyroidism Hypothyroidism Parkinsons Disease Surgical Treatment Thyroid Cancer Thyroiditis Hashimoto´s Thyroiditis Hypothyroidism during Pregnancy Hashimoto's Diet: Best Foods for Hypothyroidism 

Most Popular on Medindia

Accident and Trauma Care Iron Intake Calculator The Essence of Yoga Sinopril (2mg) (Lacidipine) Blood - Sugar Chart Sanatogen Drug - Food Interactions Blood Donation - Recipients Drug Interaction Checker Daily Calorie Requirements
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Generating Thyroid Cells to Develop New Therapies for Thyroid Disorders Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests