Gene That Puts Families at Risk of Diabetes Identified

A gene thought to be critical in the regulation of insulin, the key hormone in diabetes has been identified by recent research of families with rare blood sugar conditions. The research carried out at the Queen Mary University of London, University of Exeter and Vanderbilt University could lead to the development of novel treatments for both rare and common forms of diabetes.

In addition to the more common forms of diabetes (type 1 or type 2), in about 1-2 percent of cases diabetes is due to a genetic disorder. A defective gene typically affects the function of insulin-producing cells in the pancreas, known as beta cells.

Common genetic defect for diabetes and insulinomas
The research team studied the unique case of a family where several individuals suffering from diabetes, while other family members had developed insulin-producing tumors in their pancreas. These tumors, known as insulinomas, typically cause low blood sugar levels, in contrast to diabetes which leads to high blood sugar levels.

Lead author Professor Márta Korbonits said: "We were initially surprised about the association of two apparently contrasting conditions within the same families - diabetes which is associated with high blood sugar and insulinomas associated with low blood sugar. Our research shows that, surprisingly, the same gene defect can impact the insulin-producing beta cells of the pancreas to lead to these two opposing medical conditions."

Gender - a factor in high and low blood sugar level
The team also observed that males were more prone to developing diabetes, while insulinomas were more commonly found in females, but the reasons behind this difference are as yet unknown.

Professor Korbonits added: "One exciting avenue to explore will be seeing if we can use this finding to uncover new ways to help regenerate beta cells and treat the more common forms of diabetes."

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MAFA - gene that regulates insulin production
The researchers identified a genetic disorder in a gene called MAFA, which controls the production of insulin in beta cells. Unexpectedly, this gene defect was present in both the family members with diabetes and those with insulinomas, and was also identified in a second, unrelated family with the same unusual dual picture.

This is the first time a defect in this gene has been linked with a disease. The resultant mutant protein was found to be abnormally stable, having a longer life in the cell, and therefore significantly more abundant in the beta cells than its normal version.

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Dr Donato Iacovazzo, the first author of the paper added: "We believe this gene defect is critical in the development of the disease and we are now performing further studies to determine how this defect can, on the one hand, impair the production of insulin to cause diabetes, and on the other, cause insulinomas."

Faye Riley is Research Communications Officer at Diabetes UK. She said: "At Diabetes UK, we're committed to understanding more about the causes of all types of diabetes. This research gives us important insights into the impact a change in this particular gene has on insulin-producing beta cells and how this relates to the development of a rare genetic form of diabetes. It's also a great example of how studying rarer conditions could help us learn more about more common types of diabetes."

References:

1. Goo Jun, Alisa Manning et al. Evaluating the Contribution of rare Variants to Type 2 Diabetes and Related Traits Using Pedigrees, Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1705859115

Source-Eurekalert