Caused due to mutations in the CFTR and characterized by lung, pancreas, liver and intestinal dysfunction, cystic fibrosis is a serious condition.
Approximately 15% of babies with CF are born with an obstruction of the small intestine known as meconium ileus, frequently the first sign of CF. Unlike in humans, meconium ileus occurs in 100% of newborn CF pigs.
In this issue of the Journal of Clinical Investigation, Michael Welsh and colleagues at the University of Iowa demonstrate that transgenic expression of normal CFTR in the intestine of CF pigs alleviated meconium ileus.
Over time, the pigs still exhibited other manifestations of CF, including liver and lung disease, reduced weight gain, and pancreatic destruction. These findings provide insight into the pathophysiology of CF and indicate that tissue-specific, partial gene replacement can ameliorate intestinal symptoms of CF.
Latest Child Health News
Sebum RNA could be used to detect the onset of atopic dermatitis well before the disease progresses.
New study findings from three different populations and countries show that attention and behavior problems in childhood could predict a range of adult outcomes.
Sleep patterns of infants can be anticipated based on cortisol levels during the later stages of pregnancy, says a new study to be presented at the annual meeting of SLEEP 2023.
Analyzing the earliest sex differences in language-related activities, recent research showed boys produced significantly more speech-like vocalizations (protophones) than girls.
A mother found a team at Saint Louis University's Speech-Language and Hearing Clinic that empowered her daughter to communicate with increased confidence in different settings.