Medindia
Advertisement

Gene Linked To Cold Sore Susceptibility Identified

by VR Sreeraman on October 29, 2011 at 1:49 PM

 Gene Linked To Cold Sore Susceptibility Identified
Investigators have identified a human chromosome containing a specific gene associated with susceptibility to herpes simplex labialis (HSL), the common cold sore.

Published in the Journal of Infectious Diseases and now available online, the study looks at how several genes may affect the severity of symptoms and frequency of this common infection. The findings, if confirmed, could have implications for the development of new drugs to treat outbreaks.
Advertisement

HSL outbreaks, or cold sores, are skin infections that appear with the reactivation of herpes simplex virus, a virus that infects 70 percent of the U.S. population. Cold sore outbreaks vary in frequency and severity; some people may experience symptoms rarely, only once every 5 to 10 years, while others may experience them once a month or even more frequently. In addition to investigating environmental activating factors (e.g., sunlight) that may play a role in outbreaks, researchers for some time have been looking at the possible role of genetic factors in virus susceptibility and activation.

This study, led by John D. Kriesel, MD, and colleagues from the University of Utah School of Medicine in Salt Lake City and the University of Massachusetts Medical School in Worcester, follows previous studies identifying a region of chromosome 21 as a base for genes possibly linked to cold sore outbreaks. To identify which of six possible genes in this region were associated with the frequency of outbreaks, this latest study used single nucleotide polymorphism genotyping in genome-wide, family-based linkage studies of 618 people from 43 large families. The investigators found a positive link between the frequency of outbreaks, hereditability, and the presence of a specific gene, C21orf91, on chromosome 21.
Advertisement

"While these findings await confirmation in a larger, unrelated population," the study authors note, "these findings could have important implications for the development of new drugs that affect determinants of the cold sore phenotype."

In an accompanying editorial, Anthony L. Cunningham, MD, and David Booth, MD, of the Centre for Virus Research and the Institute of Immunology and Allergy Research at Westmead Millennium Institute and the University of Sydney in Australia, note that if the findings regarding the C21orf91 gene are confirmed, additional research may then begin to determine possible therapeutic applications and whether the same gene also plays a role in recurring genital herpes.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Cold Sores Mouth Ulcers Infectious Mononucleosis Brain Freeze RSV (Respiratory Syncytial Virus) in Children 

Recommended Reading
Cold Sores
Cold Sores...
Cure for Cold Sores on the Anvil
Cold sores, the painful blemishes of the mouth caused by the herpes simplex virus, may become a ......
Genital Herpes: Myths and Facts
Genital herpes is caused by herpes simplex virus which affects the genital region. Break outs are .....
First 3D Herpes Infection Model Developed
For the first time researchers have developed a 3D herpes infection model - raising hope for the ......
Brain Freeze
Ice cream headache or brain freeze is a temporary pain due to eating or drinking a cold substance or...
Cold Sores
Herpes labialis presents as a blister or cluster of small blisters that appear at the corner or edge...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Infectious Mononucleosis
Called also the kissing diesase, Mononucleosis is an infectious disease due to infection with the Ep...
Mouth Ulcers
Mouth ulcer or a sore in the mouth is breakage of the mucosal layer in the mouth. Local traumatic in...
RSV (Respiratory Syncytial Virus) in Children
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections. RSV infect...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use