Scientists have shown that there are widespread differences in how genes- the basic building blocks of the human body- are expressed in men and women's brains.
Based on post-mortem adult human brain and spinal cord samples from over 100 individuals, scientists at the UCL Institute of Neurology were able to study the expression of every gene in 12 brain regions.
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They found that the way that the genes are expressed in the brains of men and women were different in all major brain regions and these differences involved 2.5 percent of all the genes expressed in the brain.
Among the many results, the researchers specifically looked at the gene NRXN3, which has been implicated in autism. The gene is transcribed into two major forms and the study results show that although one form is expressed similarly in both men and women, the other is produced at lower levels in women in the area of the brain called the thalamus.
![Gene Expressions And Molecular Development]( "Gene Expressions And Molecular Development")
A study shed new light on molecular tools our cells use to govern regulated gene expression. The study was led by researchers at the University of California, San Diego School of Medicine.
Overall, the study suggested that there is a sex-bias in the way that genes are expressed and regulated, leading to different functionality and differences in susceptibility to brain diseases observed by neurologists and psychiatrists.
Dr. Mina Ryten, UCL Institute of Neurology and senior author of the paper, said:
"Our study provides the most complete information so far on how the sexes differ in terms of how their genes are expressed in the brain."
The study is in Nature Communications.
Source: ANI
Gene Expressions And Molecular Development
A study shed new light on molecular tools our cells use to govern regulated gene expression. The study was led by researchers at the University of California, San Diego School of Medicine.
Overall, the study suggested that there is a sex-bias in the way that genes are expressed and regulated, leading to different functionality and differences in susceptibility to brain diseases observed by neurologists and psychiatrists.
Dr. Mina Ryten, UCL Institute of Neurology and senior author of the paper, said:
"Our study provides the most complete information so far on how the sexes differ in terms of how their genes are expressed in the brain."
The study is in Nature Communications.
Source: ANI
Changes in Gene Expression Associated With 'Pouchitis' After Ulcerative Colitis Surgery
A study in Inflammatory Bowel Diseases says that pouchitis after surgery for ulcerative colitis (UC) is associated with changes in gene expression.
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 DNA Changes During Pregnancy may Interfere With Gene Expression During ChildhoodEven before babies are born, they accumulate changes in their DNA through a process called DNA methylation that may interfere with gene expression and in turn, their health as they grow up. |
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