About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Gene Behind Debilitating Lung Disease Identified

by Rajashri on September 15, 2008 at 2:52 PM
Font : A-A+

 Gene Behind Debilitating Lung Disease Identified

A gene that acts as a "master switch" to turn on numerous antioxidant and pollutant-detoxifying genes to protect the lungs from environmental pollutants, such as cigarette smoke, has been identified by an Indian-origin researcher at the Johns Hopkins Bloomberg School of Public Health.

Associate Professor Shyam Biswal studied lung tissue samples from patients with chronic obstructive pulmonary disease (COPD), and found that expression of the regulating gene NRF2 was significantly decreased in smokers with advanced stage of the condition as compared to normal subjects.

Advertisement

Biswal previously identified that disruption of NRF2 expression in mice caused early onset and severe emphysema, which is a major component of COPD in human.

However, the status of this critical pathway in humans with COPD was unclear.

"This work clearly demonstrates that decline in our antioxidant system is involved in progression of COPD, which could also be the case for other environmental diseases. There is no treatment of COPD, but NRF2 could be a novel target for the development of new drug therapies," said Biswal.
Advertisement

Dr. Rubin Tuder, a University of Colorado expert who is a co-author of the study, said: "As we learn how the protective actions of NRF2 are decreased in the course of a lifetime of exposure to cigarette smoke, it opens new venues for the development of novel drugs fitted for individual patients in specific stages of the disease."

The study has been published in the American Journal of Respiratory and Critical Care Medicine.

Source: ANI
RAS/L
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Respiratory Disease News

Urgent Need to Address Tuberculosis in South Africa
In South Africa, the cases of tuberculosis continue to rise making it as the primary cause of ill health and mortality.
Influenza Treatment: Are Antibiotics Effective?
Among patients with influenza, unnecessary prescription of antibiotics is found to have a significant impact on the growing threat of antimicrobial resistance.
What Are the Lessons Learned from the Tuberculosis Vaccine Rollout?
India is left with 32 months (2025) to end tuberculosis and Nigeria is left with 92 months (2030) respectively.
 Can New Medtech Help India Fight Tuberculosis?
Globally every year tuberculosis affects more than 10 million people. India contributes to 30% of the global tuberculosis burden.
Bitter Taste Receptors May Save You from Asthma and COPD
People suffering from asthma or Chronic obstructive pulmonary disease (COPD) might one day benefit from new treatments that trigger bitter taste receptors.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Gene Behind Debilitating Lung Disease Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests