About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Gene Altered Tomatoes Reduce Plaque Build-up

by Sheela Philomena on November 6, 2012 at 11:35 AM
Font : A-A+

 Gene Altered Tomatoes Reduce Plaque Build-up

In mice, genetically engineered tomatoes produce a peptide that mimics the actions of good cholesterol. In the study, mice that ate the freeze-dried, ground tomatoes had less inflammation and reduced atherosclerosis (plaque build-up in the arteries).

"We have found a new and practical way to make a peptide that acts like the main protein in good cholesterol, but is many times more effective and can be delivered by eating the plant," said Alan M. Fogelman, M.D., senior author of the study and executive chair of the Department of Medicine and director of the Atherosclerosis Research Unit in the David Geffen School of Medicine at UCLA.

Advertisement

Researchers genetically engineered the tomatoes to produce 6F, a small peptide that mimics the action of ApoA-1, the chief protein in high density lipoprotein (HDL or "good" cholesterol). They fed the tomatoes to mice that lack the ability to remove low density lipoprotein (LDL or "bad" cholesterol) from their blood and readily develop inflammation and atherosclerosis when consuming a high-fat diet.

After the mice ate the tomatoes as 2.2 percent of their Western-style high-fat, calorie-packed diet, those given the peptide-enhanced tomatoes had significantly lower blood levels of inflammation, higher paraoxonase activity ( an anti-oxidant enzyme associated with good cholesterol and related to a lower risk of heart disease), higher levels of good cholesterol,
Advertisement

decreased lysophosphatidic acid (a tumor promoter that accelerates plaque build-up in arteries in animal models) and less atherosclerotic plaque.

"To our knowledge this is the first example of a drug with these properties that has been produced in an edible plant and is biologically active when fed without any isolation or purification of the drug," Fogelman said.

Co-authors are Arnab Chattopadhyay, Ph.D.; Mohamad Navab, Ph.D.; Greg Hough, B.S.; David Meriwether, B.S.; Gao Feng, Ph.D.; Victor Grijalva, B.S.; James R. Springstead, Ph.D.; Mayakonda N. Palgunachari, Ph.D.; Ryan Namiri-Kalantari, B.S.; G.M. Anantharamaya, Ph.D.; Robin Farias-Eisner, M.D., Ph.D.; and Srinivasa T. Reddy, Ph.D. Author disclosures are on the abstract.

The researchers reported their finding at the American Heart Association's Scientific Sessions 2012.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Weaver Syndrome Food Combinations that Affect Your Well-being Peyronie´s Disease 

Most Popular on Medindia

Indian Medical Journals Noscaphene (Noscapine) Accident and Trauma Care Drug Interaction Checker Vent Forte (Theophylline) The Essence of Yoga Pregnancy Confirmation Calculator Selfie Addiction Calculator Blood Pressure Calculator Blood Donation - Recipients
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR