About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Gender Matching in Heart Transplantation Leads to Long-term Survival

by VR Sreeraman on November 15, 2008 at 1:01 PM
Font : A-A+

Gender Matching in Heart Transplantation Leads to Long-term Survival

A new study has revealed that gender matching between donors and recipients is important to short- and long-term survival in heart transplantation,

"In clinical transplantation, we generally don't assume that organs from male and female donors have inherent differences affecting long-term outcomes, but our data suggest that there are important differences which must be taken into account," said Eric Weiss, M.D., first author of the study and a post doctoral research fellow in the Division of Cardiac Surgery at The Johns Hopkins University Medical Institutions in Baltimore, Md.

Advertisement

For the study, the researchers analyzed data from the United Network of Organ Sharing (UNOS), identifying 18,240 patients who received their first orthotopic (replacing a failing organ with a healthy one) heart transplant between 1998 and 2007. In this dataset, patients were followed for 10 years, with the average follow-up time being 3.4 years.

Patients were sorted into four groups: male donor with male recipient, female donor with male recipient, male donor with female recipient, and female donor with female recipient.
Advertisement

Overall, 71 percent were matched by gender to their donor (77 percent of male recipients and 51 percent of female recipients). Twenty-five percent of patients died during the study.

The researchers found that matching donor and recipient by gender resulted in 13 percent lower risk of graft rejection within the first year; 14 percent lower rate of graft rejection over the study period; 25 percent drop in 30-day death rate; and 20 percent lower one-year death rate.

Statistical modelling revealed that the greatest chance for death during the study occurred when pairing a male donor with a female recipient, which made the risk of death an estimated 20 percent higher compared to a male donor with male recipient.

The most successful transplants occurred between male recipients and male donors, when the cumulative chance for survival was 61 percent.

"These results fit with our hypothesis that sex matching in heart transplantation leads to improved survival rates. We hypothesized that we would see a big difference in the short-term survival - which we did, most likely because of heart-size issues - but what was interesting was the substantial difference in the long term, as well," said Weiss.

The study has been presented at the American Heart Association's Scientific Sessions 2008.

Source: ANI
LIN
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Organ Donation News

 COVID-19 Positive Donor Hearts Lower Survival in Transplant Patients
An analysis of data from donors suggests donor hearts from patients who were COVID-19 positive could place transplant patients at increased risk of mortality.
 Clinical Trial Suggests Paradigm Shift for Lung Transplantation
Patients subjected to delayed transplantation using 10C static lung preservation had a better outcome compared to patients transplanted performed using standard methods.
New Method to Treat Chronic Transplant Rejection Discovered
Researchers are hoping to test the antibody IL-15 in organ transplant patients to reduce chronic organ rejection.
 Identifying Patients Who Need Liver Transplants Faster
Research may speed the identification of patients who need liver transplants by analyzing blood samples to look for biomarkers associated with liver failure.
How Can T Cells Help Prevent Marrow Transplant Complications?
The discovery of T cells involvement in graft-versus-host disease is a vital step in finding more effective life-saving treatments for bone marrow transplant.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Gender Matching in Heart Transplantation Leads to Long-term Survival Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests