A gene which controls the body's biological clock acts differently in men versus women and may protect women from heart disease, reports a new study. The findings of the study are published in the American Journal of Physiology-Regulatory, Int. & Comparative Physiology.
The study is the first to analyze circadian blood pressure rhythms in female mice.
The body's circadian clock the biological clock that organizes bodily activities over a 24-hour period contributes to normal variations in blood pressure and heart function over the course of the day.
Previous research has shown that male mice that are missing one of the four clock genes (PER1) become non-dippers and have a higher risk for heart and kidney disease.
A research team studied the circadian response and blood pressure of female mice that lack PER1 and compared them with a healthy female control group. On both low and high-salt diets, both groups "retained an apparent circadian rhythm" of blood pressure, the researchers explained. Unlike the male mice in previous research, the females without PER1 showed normal dips in blood pressure overnight.
These results suggest that the lack of PER1 acts differently in males and females. The findings are consistent with research showing that premenopausal women are less likely to be non-dippers than men of the same age. "This study represents an important step in understanding sex differences in the regulation of cardiovascular function by the circadian clock," the researchers wrote.