About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Future for Infarct Size Quantification Pinned on Echocardiography

by Nancy Needhima on December 11, 2011 at 10:24 PM
Font : A-A+

Future for Infarct Size Quantification Pinned on Echocardiography

Until date infarct size has been evaluated solely as a component of clinical studies and not incorporated in habitual clinical practice.

"Up until now infarct size has only been measured as part of clinical studies and not in routine clinical practice. The reason being that the reference method of gadolinium based contrast agents in MRI is expensive, takes a great deal of time to perform, and can only be undertaken by imaging specialists," explains EAE president Dr Luigi Badano, from the University of Padua, Italy. "The advantages of STE over MRI is that it's far quicker to use, cheaper, and can be used by cardiologists at the bedside with portable machines, and repeated serially when ever needed."

Advertisement

Additionally, STE can be applied even in patients with contraindications for MRI, such as metallic devices, claustrophobia, and severe renal failure that preclude use of contrast infusions. "The studies presented here open the way for every patient who is admitted to hospital with STEMI to undergo assessment of infarct size with echocardiography prior to discharge," says Badano.

Infarct size matters for determining how well patients will recover from STEMI. Statistics suggest that people who suffer damage to more than 30% of the left ventricle are twice as likely to die within a year of the event than people who suffer less damage. "It's well known that patients with larger infarcts are more likely to undergo alterations in the structure (dimensions, mass and shape) of the left ventricle, known as cardiac remodelling, which leads to heart failure," says Badano.
Advertisement

Evidence is mounting, he adds, that screening for patients with larger infract sizes enables identification of patients with a worse prognosis who benefit from more aggressive therapy and more frequent follow-up visits. "Nowadays many more options exist for STEMI patients deemed at high risk of adverse events, including prescription of ACE inhibitors and insertion of devices like CRT cardiac resynchronisation or ICDs", says Badano.

Speckle tracking echocardiography (STE) is a comparatively new non-invasive echocardiography technique well suited to quantifying infarct size. It works by tracking the movement of natural acoustic markers or "speckles" which are present on standard grey ultrasound tissue images. With the use of wall motion tracking software, speckle movement (and therefore myocardial tissue movement) can be visualised during the cardiac cycle. Speckle-tracking can be used to evaluate myocardial strain, which describes the myocardial deformation throughout the cardiac cycle. Reductions in measurement of strain, have been found to show direct relationships to the size of the infarct.

First use of 3D speckle-tracking to estimate infarct size following STEMI

Measuring circumferential strain with 3D speckle-tracking provides a good predictor of infarct size after STEMI , finds an Italian studyš.

In the study, which presents the first data on use of 3D speckle-tracking in measuring infarct size, Dr Denisa Muraru and colleagues from the University of Padua (Italy), estimated infarct size and necrosis transmurality in patients with recent STEMI, who had undergone successful treatment with primary PCI. One of the advantages of 3D speckle-tracking over 2D, say the authors, is that it allows the assessment of longitudinal (apex-to-base shortening), circumferential (shortening in the circumferential direction); radial strain (myocardialwall thickeningtowards LV cavity center) and area strain (a deformation parameter combining longitudinal and circumferential strain) at the same time. In the study, 49 patients with recent STEMI, successfully reperfused with primary PCI were assessed by 3D speckle-tracking, and the obtained LV strain parameters were compared with peak troponin I levels, as an estimate of the extent of myocardial cell injury. In a multivariable analysis, results showed that only circumferential strain emerged as a significant independent predictor of infarct size. Furthermore, in the subgroup of 27 patients who underwent additional assessment with delayed-enhancement MRI within 24 hours from the echocardiographic study, circumferential strain again showed the closest correlation with infarct size and the best predictive power to identify LV segments with transmural necrosis among all strain components.

"Our preliminary study demonstrates that 3D circumferential strain could be used as an accurate and reproducible marker for infarct size estimation by ultrasound in STEMI patients," says Muraru. Long term follow-up, she adds, will be needed to verify if 3D strain parameters improve the predictive prognostic value of conventional parameters after STEMI.

Study uses 2D speckle tracking to predict infarct size

Longitudinal strain measured early after reperfusion with 2D speckle-tracking may predict infarct size and LV remodelling, concludes a Bulgarian study ˛.

In the study, Dr Krasimira Hristova and colleagues, from the University National Heart Hospital (Sofia, Bulgaria) investigated the ability of speckle-tracking echocardiography using the vector velocity imaging technique (which measures both the amount of strain and the direction of strain) to determine infarct size.

In the study 30 patients who had PCI for an acute MI within 24 hours and 20 normal volunteers (who had not experienced an event) were assessed with both vector velocity speckle-tracking and intracoronary electrocardiography. The later technique is an established procedure that maps areas of ischemia with guide wires during percutaneous procedures, providing the exact location and size of residual ischemia.

The results showed that in patients who had suffered STEMI radial and circumferential strain decreased in the infarct area , perinfarct area (immediate area around the infarct) and remote regions acutely in comparison with controls; but that longitudinal strain was only decreased in the actual infarct area and not in the perinfarct and remote regions.

"While longitudinal strain shows the best relationship to infarct size, we believe that radial and circumferential strain may be useful to predict the later development of adverse LV remodelling," says Hristova.

In the next part of the study, she adds, they hope to be able to compare their initial results for longitudinal, radial and circumferential strain with the longer term effects on left ventricular remodelling.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cardiomyopathy Infective Endocarditis 

Most Popular on Medindia

Iron Intake Calculator Calculate Ideal Weight for Infants Drug Side Effects Calculator Vent Forte (Theophylline) Diaphragmatic Hernia Blood - Sugar Chart Loram (2 mg) (Lorazepam) Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Indian Medical Journals
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Future for Infarct Size Quantification Pinned on Echocardiography Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests