Fresh Insights into Treatment of Parkinson’s Disease

With many advances in treatments for Parkinson’s disease, there still exist some hurdles that have resulted in treatment failure; the reasons for failure of treatment were described, with hope separated from hype.

New therapeutic strategies have emerged over recent years to treat Parkinson’s disease (PD) including gene- and stem cell- based therapies, targeted delivery of neurotrophic factors, and brain stimulation techniques such as Transcranial Magnetic //Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS), said researchers.

Despite the numerous advances in cutting-edge approaches for the treatment or prevention of PD, there still exists some obstacles that have incapacitated the definitive treatment of this disease.

Nutritional Management of Parkinson's Disease
Parkinson's disease is a brain disorder which leads to many other related effects. Nutrition plays an important role in management of the disease.

‘Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor deficits majorly caused by the loss of dopaminergic cells in the Substantia Nigra pars compacta (SNc) as well as the destruction of nigrostriatal pathway. ’

The review covers various gene therapy strategies including Adeno-Associated Virus-Glutamic Acid Decarboxylase (AAV-GAD), AAV-Aromatic L-Amino Acid Decarboxylase (AAV-AADC), Lenti-AADC/Tyrosine Hydroxylase/Guanosine Triphosphate- Cyclohydrolase I (Lenti-AADC/TH/GTP-CH1), AAV-Neurturin (AAV-NRTN), α-Synuclein silencing, and PRKN gene delivery. The review also covers the advantages and disadvantages of these treatments along with the results of relevant trials.

Source-Eurekalert

Parkinson’s Disease - Causes, Symptoms, Diagnosis, Treatment
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. Symptoms of Parkinson’s disease are correctable to an extent.

Quiz on Parkinson’s Disease
Parkinson's disease (PD) is a chronic and progressive nervous system disorder that results in a gradual loss of muscle control. It has an impact on the body's ability to control movement.

How Do Parkinson's Causing Protein Clumps Damage Brain Cells?
Scientific mystery solved: How do protein clumps damage brain cells to cause Parkinson's Disease found.