About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Food Allergies Linked to Atopic Dermatitis in Pediatrics

by Mohamed Fathima S on February 21, 2019 at 5:10 PM
Font : A-A+

Food Allergies Linked to Atopic Dermatitis in Pediatrics

Food allergies are associated with various abnormalities in seemingly-healthy skin in pediatric patients suffering from atopic dermatitis (AD). AD is a common skin disorder also known as eczema that makes the skin turn red and itchy. It is long lasting which tends to flare up periodically.

The surprising findings represent one of the most comprehensive skin-related assessments of AD patients to date, and hint that treatments for AD and food allergy should focus on improving the function of the skin barrier.

Advertisement


Atopic dermatitis is an inflammatory skin disorder that affects nearly 20% of children worldwide, and one-third of AD patients also have food and respiratory allergies. Scientists have sought to better understand the relationship between AD and food allergy, but progress has been limited because skin sampling methods such as biopsies are overly invasive.

Here, Donald Leung and colleagues used a noninvasive sampling approach named skin tape stripping to study the skin of 21 patients with AD and food allergy (FA+), 19 patients with AD and no food allergy (FA-) and 22 healthy controls. Their analysis revealed that nonlesional skin from the AD FA+ patients had unique properties not seen in the AD FA- patients. Specifically, the AD FA+ skin samples showed decreased amounts of a skin-associated protein named filaggrin, elevated type 2 immune responses (a form of immune activity mediated by T helper cells) and increased expression of the skin-associated protein keratin - abnormalities that correlated with structural changes in skin barrier architecture. Nonlesional AD-FA+ skin also harbored a higher amount of the bacterial species Staphylococcus aureus compared to AD FA- patients and controls.

Future studies should further examine the complex relationships between S. aureus overgrowth, reduced filaggrin and food allergy sensitization in patients, the authors say.



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Child Health News

Anesthesia Drug Beneficial for Treating Brain Injury in Children
Researchers are studying the effect of ketamine in a large study to identify possible treatment for traumatic brain injury.
Is There a Link Between Pediatric Hepatitis and Common Childhood Viruses?
In kids the clusters of acute severe hepatitis are diminished, but researchers stress parents to pay attention to children's personal hygiene to keep the liver disease away.
 Movement Analysis in Infancy may be Useful for Autism Diagnosis
New study findings advance the understanding of the neural organization of infants' basic visual processing, and its role in the development of autism.
 List of Do's and Don'ts for Vaccination in Infants
What precautions should be taken after vaccination in newborn? Check out some essential dos and don'ts of vaccinating to make informed decisions about their health.
 Virtual Reality Exploring Brain Structure Changes in Autism
Virtual reality-based imaging system provides crucial information to understand dynamics of brain network linked to behavioral abnormality of autism.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Food Allergies Linked to Atopic Dermatitis in Pediatrics Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests