Kidney stones affect just over 7% of adults, and that number
has been on the rise. Though previous studies have identified a
long-term risk of chronic kidney disease in kidney stone formers, prior
research has not assessed kidney function immediately after their first
Mayo Clinic nephrologists have uncovered a connection between first-time kidney stone formers and chronic kidney disease. In a paper published today in Mayo Clinic Proceedings, researchers announce a persistent decline in kidney functioning following an individual's first case of kidney stones.
A Mayo Clinic team led by William Haley and Andrew Rule assessed a group of 384 stone formers three months after their first stone event to study the effect of kidney stones on their kidney function. Compared to the control group, kidney stone formers maintained higher levels of the blood marker cystatin C and higher levels of urine protein - both of which are connected with higher risk of chronic kidney disease.
The small, hard mineral deposits that characterize kidney stones can cause severe pain, nausea and difficulty passing urine. An increased risk of chronic kidney disease, however, could make the condition one that has a more long-term impact on an individual's health.
"This research shows that the implications of kidney stones may go beyond the discomfort they are so often associated with," says Dr. Rule. "Prevention of kidney stones may be beneficial for a person's overall kidney health."