One gene called SpdC might be responsible for the virility, and antibiotic resistance of Staphylococcus aureus bacteria finds a new study. The findings of this study are published in the journal of PLoS Pathogens.
Staphylococcus aureus is part of the natural skin flora, preferentially colonizing external mucosa in 30 to 50% of the population, healthy carriers who develop no symptoms. But it is also a major human pathogen, causing diseases ranging from skin lesions (boils, impetigo, etc.) to endocarditis, acute pneumonia, osteomyelitis or sepsis.
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Bacteria deposited on a surface by one person touching it, or via contaminated body fluids, can be picked up by subsequent users and spread to other surfaces.
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‘Inhibition of SpdC could be used as an approach to combat S. aureus infections. SpdC, a membrane protein can interact with the WalKR system to control its activity. Its absence can lead to a strong decrease in virulence, biofilm formation (bacterial aggregates), and resistance to certain antibiotics.’
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Staphylococcus aureus is the leading Gram-positive bacterium responsible for nosocomial infections (hospital acquired infections). The most dangerous strains are those that display resistance to multiple antibiotics. This is the case of MRSA[1], resistant to Meticillin, widespread in hospitals and posing a major public health concern.
The Signaling and Pathogenesis of Staphylococci team, led by Tarek Msadek, a researcher in the Biology of Gram-positive Pathogens Unit at the Institut Pasteur (CNRS ERL 3526), is studying bacterial responses to environmental variations and their role in staphylococcus aureus pathogenesis and host interactions. These responses are often genetically controlled by so-called "two-component" systems.
![Humans can Give Monkeys Staphylococcus Aureus Bacteria]( "Humans can Give Monkeys Staphylococcus Aureus Bacteria")
While humans acquired many deadly diseases originally through contact with animals, pathogens can also jump the species barrier to move from humans to animals.
During the study of one of these systems, WalKR, essential for bacterial survival, they characterized an additional component, SpdC, a membrane protein whose role was unknown. This component interacts with the WalKR system to control its activity, and its absence leads to a strong decrease in virulence, biofilm formation (bacterial aggregates), and resistance to certain antibiotics.
These results suggest that inhibition of SpdC could be used as an approach to combat S. aureus infections and understand the mechanisms involved in its transition from commensal to a pathogen.
Source: Eurekalert
Humans can Give Monkeys Staphylococcus Aureus Bacteria
While humans acquired many deadly diseases originally through contact with animals, pathogens can also jump the species barrier to move from humans to animals.
Advertisement
During the study of one of these systems, WalKR, essential for bacterial survival, they characterized an additional component, SpdC, a membrane protein whose role was unknown. This component interacts with the WalKR system to control its activity, and its absence leads to a strong decrease in virulence, biofilm formation (bacterial aggregates), and resistance to certain antibiotics.
These results suggest that inhibition of SpdC could be used as an approach to combat S. aureus infections and understand the mechanisms involved in its transition from commensal to a pathogen.
Source: Eurekalert
Methicillin Resistant Staphylococcus Aureus Shows Decline in SE Michigan
Emergent strain of methicillin-resistant S. aureus (MRSA) that is resistant to last line defense antibiotics has shown a decline, reveals a study.
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Beneficial Bacteria in the Nose Suppress the Staphylococcus Aureus BacteriaHow harmless Corynebacterium species, bacterial members of the nasal and skin microbiome, help protect humans from disease has been revealed by scientists. | Advertisement
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