Rabies is transmitted through the bites of infected dogs and foxes. It is a viral disease that kills tens of thousands of people every year, predominantly in Africa and Asia. Symptoms include fever, headaches, and weakness.
In West- and Central Europe, rabies was eliminated some 20 years ago. Switzerland was declared free of rabies in 1999 after implementing a strategy targeting foxes.
Rabies in Africa can be Eliminated
Rabies, a viral disease, transmitted through the bites of infected dogs and foxes can be eliminated. However, first eliminating the dog rabies in Africa is essential.
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‘Study provides an important proof-of-concept for the Global Alliance for Rabies Control and the Pan-african Rabies Control Network that rabies elimination in Africa can be achieved.’
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"If you want to prevent humans from dying from rabies in Africa and Asia, you need to eliminate dog rabies," said Jakob Zinsstag from the Swiss Tropical and Public Health Institute (Swiss TPH), first author and principal investigator of a study in Science Translational Medicine. Swiss TPH, together with collaborators in Europe and in Africa, demonstrated the proof-of-concept that elimination of rabies is feasible. "We have shown that African teams in one of the poorest countries can eliminate human rabies through mass vaccination of dogs. What is needed next is additional funding and a concerted political will," said Zinsstag, an epidemiologist and veterinary public health expert.
The investigation was carried out in N'Djamena, the capital of Chad where 1.1 million people live alongside some 30,000 dogs. In 2012 and 2013, 20,000 dogs were vaccinated each year against rabies. Hence, more than 65% of the city's estimated dog population participated in the intervention, "an excellent coverage rate," said Zinsstag. "We mobilised the neighbourhood chiefs and they in turn mobilised the people and their dogs."
![Vaccinating Dogs can Reduce Rabies Deaths in India]( "Vaccinating Dogs can Reduce Rabies Deaths in India")
Vaccinating two lakh stray dogs a year would significantly reduce incidence of rabies at a cost of about $1.27 million annually.
A model African-European collaboration
Swiss TPH is a world-leading institute in the field of human and animal health - increasingly known as "One Health" - and maintains a productive collaboration with Chad dating back to the 1990s. Swiss TPH collaborated with a public-private partnership in Chad, namely the Centre de Support en Santé Internationale (CSSI) and the Institut de recherche en élevage pour le développement (IRED). An additional player was the Laboratoire Central Vétérinaire (LCV) in Bamako, Mali.
For the genetic analyses of collected rabies viruses, Swiss TPH was supported by the ETH Zurich in Basel, Switzerland, and by the Institut Pasteur in Paris, France. At Swiss TPH, an interdisciplinary team was estab-lished with expertise in molecular diagnostics, mathematical modelling and veterinary epidemiology. "The mathematical modelling shows that the reproductive number, that is the number of secondary infections for one rabies-infected dog, fell under one, hence transmission is interrupted, and a molecular analysis shows that the circulating strains disappear," said Zinsstag and Nakul Chitnis, a co-investigator at Swiss TPH.
Further insights through phylodynamics
The study is one of the first research projects to apply a rigorous phylodynamic method to dog rabies, and hence, it expands upon the normative phylogenetics (i.e. assessing the genetic relatedness of virus strains) with the dynamics of transmission over time. This made it possible to calculate the reproductive number of rabies among the dogs after the first mass dog vaccination in 2012.
"Dog rabies was likely re-introduced through the import of dogs by humans from outside N'Djamena after the rabies elimination had been achieved," Zinsstag explains.
The phylogenetic analysis supports this finding, since the sequence of nucleoprotein of the new viruses showed a different genetic structure. "The molecular method ascertained the results put forth by the mathematical model through an independent approach," said Zinsstag. "Therefore eliminating rabies is not a technical problem, but a matter of political will and sufficient financial resources."
The Swiss TPH study was financially supported by the UBS Optimus Foundation in Switzerland (vaccine, epidemiological field work and laboratory investigations). The Chadian government covered other costs (logistics and personnel).
Towards elimination of rabies in Central and West Africa
Eliminating dog mediated human rabies by 2030 is part of the Sustainable Development Goals (SDGs). "It will be a formidable challenge to reach this SDG goal by then, but we can prevent people from dying from dog-transmitted rabies," said Zinsstag. "Our study provides an important proof-of-concept for the Global Alliance for Rabies Control (GARC) and the Pan-african Rabies Control Network (PARACON) that rabies elimination in Africa indeed can be achieved."
As a next step, Swiss TPH and its partners plan to extend mass dog vaccination against rabies across Chad. "We have calculated that with 28 million euros, it would be possible to eliminate rabies throughout the country. However, an important challenge is migration: once Chad is free from rabies, the disease might be re-imported from neighbouring countries such as Cameroon and Sudan. We therefore need a concerted Pan Central and West African approach, led by the Economic Unity of West African States ECOWAS and the African Union.
This would bring along the additional benefit of promoting peace through cooperation." Zinsstag estimates that in order to free Central and West Africa from rabies, the costs would amount to around 1 billion euro over a 20-year period.
One Health rabies research at Swiss TPH
Swiss TPH maintains a West African research network in the field of human and animal health based on an excellent collaboration with many African partners, such as CSSI in Chad and the Centre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), among others. Swiss TPH pursues a two-pronged approach with the overall aim of eliminating rabies in humans: eliminating dog rabies and making post-exposition prophylaxis accessible to all people in West and Central Africa. For this last approach, Swiss TPH collaborates with the Global Vaccine Alliance (GAVI).
One Health is, in Zinsstag's own words, the "added value of a close collaboration of human and animal health. If medical experts and veterinarians work together more closely, they can improve health to a greater extent than they could alone."
The concept of One Health was instigated by the veterinary epidemiologist Calvin W. Schwabe in the 1960s. Swiss TPH has developed the scientific theory behind it as well as the associated teaching and training. For instance, Swiss TPH developed the first massive open online course (MOOC) in One Health, which is now being offered in its second year.
Source: Eurekalert
Vaccinating Dogs can Reduce Rabies Deaths in India
Vaccinating two lakh stray dogs a year would significantly reduce incidence of rabies at a cost of about $1.27 million annually.
Advertisement
A model African-European collaboration
Swiss TPH is a world-leading institute in the field of human and animal health - increasingly known as "One Health" - and maintains a productive collaboration with Chad dating back to the 1990s. Swiss TPH collaborated with a public-private partnership in Chad, namely the Centre de Support en Santé Internationale (CSSI) and the Institut de recherche en élevage pour le développement (IRED). An additional player was the Laboratoire Central Vétérinaire (LCV) in Bamako, Mali.
For the genetic analyses of collected rabies viruses, Swiss TPH was supported by the ETH Zurich in Basel, Switzerland, and by the Institut Pasteur in Paris, France. At Swiss TPH, an interdisciplinary team was estab-lished with expertise in molecular diagnostics, mathematical modelling and veterinary epidemiology. "The mathematical modelling shows that the reproductive number, that is the number of secondary infections for one rabies-infected dog, fell under one, hence transmission is interrupted, and a molecular analysis shows that the circulating strains disappear," said Zinsstag and Nakul Chitnis, a co-investigator at Swiss TPH.
Further insights through phylodynamics
The study is one of the first research projects to apply a rigorous phylodynamic method to dog rabies, and hence, it expands upon the normative phylogenetics (i.e. assessing the genetic relatedness of virus strains) with the dynamics of transmission over time. This made it possible to calculate the reproductive number of rabies among the dogs after the first mass dog vaccination in 2012.
"Dog rabies was likely re-introduced through the import of dogs by humans from outside N'Djamena after the rabies elimination had been achieved," Zinsstag explains.
The phylogenetic analysis supports this finding, since the sequence of nucleoprotein of the new viruses showed a different genetic structure. "The molecular method ascertained the results put forth by the mathematical model through an independent approach," said Zinsstag. "Therefore eliminating rabies is not a technical problem, but a matter of political will and sufficient financial resources."
The Swiss TPH study was financially supported by the UBS Optimus Foundation in Switzerland (vaccine, epidemiological field work and laboratory investigations). The Chadian government covered other costs (logistics and personnel).
Towards elimination of rabies in Central and West Africa
Eliminating dog mediated human rabies by 2030 is part of the Sustainable Development Goals (SDGs). "It will be a formidable challenge to reach this SDG goal by then, but we can prevent people from dying from dog-transmitted rabies," said Zinsstag. "Our study provides an important proof-of-concept for the Global Alliance for Rabies Control (GARC) and the Pan-african Rabies Control Network (PARACON) that rabies elimination in Africa indeed can be achieved."
As a next step, Swiss TPH and its partners plan to extend mass dog vaccination against rabies across Chad. "We have calculated that with 28 million euros, it would be possible to eliminate rabies throughout the country. However, an important challenge is migration: once Chad is free from rabies, the disease might be re-imported from neighbouring countries such as Cameroon and Sudan. We therefore need a concerted Pan Central and West African approach, led by the Economic Unity of West African States ECOWAS and the African Union.
This would bring along the additional benefit of promoting peace through cooperation." Zinsstag estimates that in order to free Central and West Africa from rabies, the costs would amount to around 1 billion euro over a 20-year period.
One Health rabies research at Swiss TPH
Swiss TPH maintains a West African research network in the field of human and animal health based on an excellent collaboration with many African partners, such as CSSI in Chad and the Centre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), among others. Swiss TPH pursues a two-pronged approach with the overall aim of eliminating rabies in humans: eliminating dog rabies and making post-exposition prophylaxis accessible to all people in West and Central Africa. For this last approach, Swiss TPH collaborates with the Global Vaccine Alliance (GAVI).
One Health is, in Zinsstag's own words, the "added value of a close collaboration of human and animal health. If medical experts and veterinarians work together more closely, they can improve health to a greater extent than they could alone."
The concept of One Health was instigated by the veterinary epidemiologist Calvin W. Schwabe in the 1960s. Swiss TPH has developed the scientific theory behind it as well as the associated teaching and training. For instance, Swiss TPH developed the first massive open online course (MOOC) in One Health, which is now being offered in its second year.
Source: Eurekalert
Rabies Vaccine Found to be Effective Even in Limited Refrigeration Facilities
Scientists find Rabies vaccine to be effective even in warm storage conditions where there is limited cooling facilities.
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Nagaland Conducts Anti-Rabies Vaccination Camps On ‘World Rabies Day’Training and seminars on rabies would be initiated by Kohima Municipal Council, where two persons from each ward would be trained to contain the disease. | Advertisement
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