About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Fat Metabolism Linked to Increased Risk of Heart Disease in Diabetics

by VR Sreeraman on August 12, 2007 at 12:37 PM
Font : A-A+

Fat Metabolism Linked to Increased Risk of Heart Disease in Diabetics

Researchers at Washington University School of Medicine in St. Louis have linked abnormal fat metabolism to increased risk of heart disease in diabetics.

Earlier, Richard Gross and colleagues had found that an important lipid, cardiolipin, which has unusual physical properties that are essential for the operation of the energy-producing cell structures called mitochondria is decreased during diabetes.

Advertisement

When mitochondria lose a lot of their cardiolipin, they malfunction that not only interferes with the energy supply of heart muscle cells, but also increases the amount of damaging oxygen-containing substances in the cells, creating unhealthy conditions that can lead to heart problems.

Researchers identified a particular lipid-digesting enzyme that becomes more active in diabetic heart muscle and contributed to the breakdown of cardiolipin.
Advertisement

As part of this study, researchers used a highly sophisticated set of techniques called 'shotgun lipidomics' which very rapidly determine which lipids are in tissues and blood, to measure cardiolipin in engineered mice.

The study found that cardiolipin dramatic depleted in heart muscle as early as five days after diabetes was induced in mice.

Researchers found that mice engineered to produce too much of cardiolipin, developed defects in mitochondrial function, which worsened when they were, fasted, a condition that, like diabetes, causes the heart to use lipids for fuel.

The study found that a 16-hour fast caused significant problems with the mouse hearts' ability to pump blood, again implicating altered lipid metabolism, cardiolipin scarcity and mitochondrial impairment in heart disease using lipid as predominant fuel.

Researchers also noted that in addition to the effects on mitochondria, many of the membranes in heart cells, which are built from fatty molecules, were also adversely affected by the diabetic heart's abnormal lipid metabolism. Furthermore, because fatty molecules are part of cells' signalling mechanisms, numerous aspects of cellular physiology become altered.

Source: ANI
SRM/S
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cochlear Implants may Consequently Drive Hearing Loss
E-cigarettes Use Linked to Erectile Dysfunction
Memory Loss - Can it be Recovered?
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Diabetes - Self-Monitoring of Blood Glucose (SMBG) Cardiac Catheterization Diabetes and Exercise Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Body Mass Index Silent Killer Diseases Cholesterol - The Enigma Chemical 

Recommended Reading
What is diabetes?
The condition of excess glucose level in bloodstream can be regulated by a regular practice of ......
Six Steps Closer To Predicting Heart Disease Risk
A joint study conducted by British and German researchers has confirmed six new genetic variants ......
Air travel: To fly or not to fly
Air travel is for everyone, even those with medical conditions....
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Cholesterol - The Enigma Chemical
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is im...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use