About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Faster Cure for TB Thanks to New Findings on Drug Tolerance

by Kathy Jones on March 6, 2011 at 9:19 PM
Font : A-A+

 Faster Cure for TB Thanks to New Findings on Drug Tolerance

A new study might change the current tuberculosis (TB) treatment that requires a complex, long-term curative regimen of at least six months.

New findings on how TB bacteria develop multi-drug tolerance suggest TB infections could be cured more quickly.

Advertisement

The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect.

TB treatment requires many months because the bacteria become tolerant to TB drugs. In the first couple days of treatment the bacteria die rapidly, but the death rate then slows to a crawl as the bacteria become resistant to killing.
Advertisement

This tolerance to antibiotics occurs despite the absence of genetic mutations for drug resistance.

Senior author Lalita Ramakrishnan from the University of Washington and Paul Edelstein of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania noted that adhering to six months of drug treatment is difficult, particularly in areas of the world where TB is prevalent.

An urgent goal is to overcome drug tolerance, yet most of the drugs in development will not shorten the lengthy treatment. This failure results from a poor understanding of the mechanism of TB tolerance.

"Drug tolerance has been largely attributed to TB bacteria that are dormant in the body and not reproducing. These postulated dormant bacteria are thought to be unaffected by the administered antibiotics that are most effective against rapidly growing organisms," said Lalita.

To understand how growing bacteria might be tolerant to drugs, the researchers turned to studying the human TB bacillus in human macrophages. They found that upon infecting macrophages, the bacteria deploy a structure called an efflux pump.

They found that these pumps are essential for the TB bacteria to grow within macrophages and are turned on possibly to get rid of host anti-microbial substances targeted to penetrate the bacteria and destroy them.

Paradoxically, it is the infected macrophage itself that stimulates the efflux pumps in the bacteria. The TB cell efflux pumps can also flush away medications, a mechanism, which may be contributing to multi-drug tolerance.

"Thus the TB drugs get caught in the crossfire in this pitched battle between bacterium and host," said Lalita.

Certain inexpensive medications are already available that can inhibit these bacterial pumps and thereby reduce multi-drug tolerance, the researchers noted.

The researchers suggested that adding this currently approved drug to TB therapy, or working to develop drugs that more specifically block the bacterial efflux pumps in TB organisms, might reduce multi-drug tolerance. If so, efflux pump inhibitors might be able to shorten the duration of curative treatment for TB.

The study will be published April 1 in the journal Cell.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Know More About Mitochondria
Top 10 Foods for Decreasing DHT Production and Preventing Hair Fall
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Tuberculosis AIDS/HIV Signature Drug Toxicity Silicosis Screening Tests for Tuberculosis 

Most Popular on Medindia

Blood Pressure Calculator Loram (2 mg) (Lorazepam) Pregnancy Confirmation Calculator Vent Forte (Theophylline) How to Reduce School Bag Weight - Simple Tips Indian Medical Journals Turmeric Powder - Health Benefits, Uses & Side Effects Drug - Food Interactions Sinopril (2mg) (Lacidipine) Blood Donation - Recipients
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE

×

Faster Cure for TB Thanks to New Findings on Drug Tolerance Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests