Universal facial masking may show an effective possibility for inducing variolation against the SARS-CoV-2 virus until we anticipate the COVID-19 vaccine.

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Population-wide face mask exposes an individual to a lower rate of SARS-CoV-2 infection. This might help with smaller dose of exposure to the virus to induce variolation against COVID-19 and reduce its severity, until the arrival of the vaccine.
The present hypothesis validated that high doses of viral exposure disrupts the immunity of a person and increases the severity of the disease and can even lead to death. Thus, by minimizing the viral exposure, this mechanism might be down-regulated which would result in an asymptomatic (milder) infection rate.
The theory was limited by insufficient studies on the strength and durability of SARS-CoV-2 – specific T-cell immunity among symptomatic and asymptomatic infections along with low COVID-19 transmission rates among asymptomatic infections.
Decreasing the transmission rates and severity of the disease helps in combating the pandemic – components that are significantly manifested by the population-wide use of facial mask – concluded the authors, from the Centre for AIDS Research, Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine (M.G.), and the Division of Infectious Disease and Global Epidemiology, Department of Epidemiology and Biostatistics (G.W.R.), University of California.
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