About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Exposure to Second-Hand Tobacco Smoke Linked to Liver Disease

by VR Sreeraman on September 13, 2009 at 1:17 PM
Font : A-A+

 Exposure to Second-Hand Tobacco Smoke Linked to Liver Disease

People can develop liver disease even when they are exposed to second-hand tobacco smoke, according to a study.

Scientists at the University of California, Riverside (UCR) have found that exposure to second-hand tobacco smoke can lead to non-alcoholic fatty liver disease (NAFLD), a common disease and rising cause of chronic liver injury wherein fat accumulates in the liver of people who drink little or no alcohol.

Advertisement

For their study, the researchers exposed some mice to second-hand cigarette smoke for a year in the lab, and observed fat build-up in their liver cells, a sign of NAFLD that eventually leads to liver dysfunction.

The researchers focused on two key regulators of lipid (fat) metabolism that are found in many human cells as well: SREBP (sterol regulatory element-binding protein) that stimulates synthesis of fatty acids in the liver, and AMPK (adenosine monophosphate kinase) that turns SREBP on and off.
Advertisement

They found that second-hand smoke exposure inhibits AMPK activity, which, in turn, causes an increase in activity of SREBP.

More active SREBP results in more fatty acids getting synthesized, they say.

The result is NAFLD induced by second-hand smoke, according to the researchers.

"Our study provides compelling experimental evidence in support of tobacco smoke exposure playing a major role in NAFLD development," said Manuela Martins-Green, a professor of cell biology, who led the study.

"Our work points to SREBP and AMPK as new molecular targets for drug therapy that can reverse NAFLD development resulting from second-hand smoke. Drugs could now be developed that stimulate AMPK activity, and thereby inhibit SREBP, leading to reduced fatty acid production in the liver," Martins-Green added.

A research article describing the study has been published in the Journal of Hepatology.

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Liver Biopsy Health Hazards of Smoking Hepatitis A Smoking And Cancer Smoking And Tobacco Diet Lifestyle and Heart Disease Liver Wilson's Disease Cigarette Smoking - A Silent Killer 

Most Popular on Medindia

Blood - Sugar Chart Vent Forte (Theophylline) Diaphragmatic Hernia Blood Donation - Recipients Indian Medical Journals Iron Intake Calculator Post-Nasal Drip Nutam (400mg) (Piracetam) Loram (2 mg) (Lorazepam) Find a Doctor
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Exposure to Second-Hand Tobacco Smoke Linked to Liver Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests