Bisphenol S (BPS) shows the potential for increasing the aggressiveness of breast cancer through its behaviour, as an endocrine-disrupting chemical.
If You are Fat, Breast Cancer Growth Becomes Aggressive
As a person becomes obese, that can change the adipose tissue, or change this microenvironment where the cancer can start or progress.
As a person becomes obese, that can change the adipose tissue, or change this microenvironment where the cancer can start or progress.
‘If a woman has a mutated BRAC1 gene and uses products containing BPS, her risk for developing breast cancer may increase further.’
The findings suggest that BPS may cause breast cancer to become more aggressive. The results, which tested BPS in human breast cancer cells, is scheduled to be presented at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Florida. "Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behaviour to BPA," said the study's principal investigator Sumi Dinda. Their study confirmed that BPS acts like estrogen in breast cancer cells, Dinda said, adding, "So far, BPS seems to be a potent endocrine disruptor." The researchers studied the effects of BPS on estrogen receptor-alpha and the BRCA1 gene. Using two commercially available breast cancer cell lines obtained from women with estrogen-receptor-positive breast cancer, the team exposed the cancer cells to varying strengths of BPS or to an inactive substance as a control.
They also treated the breast cancer cells with estradiol (estrogen) and found that BPS acted like estrogen in multiplying breast cancer cells. Compared with the control, BPS heightened the protein expression in estrogen receptor and BRCA1 after 24 hours, as did estrogen. The results indicated that after a six-day treatment with BPS, the breast cancer cells in both cell lines reportedly increased in number by 12 percent at the lowest dose (4 micromolars) and by 60 percent at 8 micromolars.
German Shepherds can Accurately Detect Breast Cancer
Attention dog lovers! With just six months of training, a German Shepherd can accurately detect breast cancer.
Attention dog lovers! With just six months of training, a German Shepherd can accurately detect breast cancer.
Source-ANI
Role of Tumor Sequencing in the Treatment of Breast Cancer
Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown.
Tumor sequencing is increasingly used to select treatment for patients with cancer, but its role in women with newly diagnosed breast cancer is unknown.
New Found Achilles' Heel in Triple Negative Breast Cancer
Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options.
Triple-negative breast cancer quickly becomes resistant to current therapies, leaving patients no therapeutic options.
