Abiraterone acetate drug found to show promising treatment for prostate cancer even after initial hormone therapy failure.

‘Hormonal Abiraterone acetate drug has been found to show positive results in treating prostate cancer despite initial failure in hormone therapy.’

There was an additional 33% patients who showed partial response to the drug and the PSA levels were ranging between 0.2 and 4ng/ml.




"We set an especially high bar with our goal of reducing PSA to below 0.2, which is very low, especially for this high-risk population. The trial did not meet its success criteria of six full responders, but we feel that with five full responders and evidence that many more patients also received some benefit from the drug, abiraterone acetate deserves more study in this population," says Thomas W. Flaig, MD, investigator at the University of Colorado Cancer Center and the trial's national primary investigator.
Flaig also points to this trial as important evidence of the evolution of hormone therapy in prostate cancer.
"We used to think that if a patient's cancer progressed despite traditional hormone therapy, that was it for hormone therapy. Now we see that's not the case. It may just be that the first drug wasn't strong enough, or that cancer became hypersensitive to any remaining androgen. Now with drugs like abiraterone we can almost completely cut off a cancer's ability to drive its growth with androgen and we see this drug working even after the initial, standard hormone therapy has failed," Flaig says.
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"This is one of the first studies to focus on this high-risk group of patients with early failure of hormone induction therapy. Seeing this level of response in patients that had previously been dubbed 'hormone resistant' reinforces our hope that this drug will help many kinds of patients in many settings," Flaig says.
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Source-Eurekalert