About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Experimental Drug Found to Reduce High Blood Pressure in Diabetics and Hypertensive Patients

by Kathy Jones on June 26, 2014 at 6:50 PM
Font : A-A+

 Experimental Drug Found to Reduce High Blood Pressure in Diabetics and Hypertensive Patients

An experimental drug, empagliflozin, developed for treating Type 2 diabetes has been found to lower blood pressure in diabetic and hypertensive patients, a new study presented at the joint meeting of the International Society of Endocrinology and The Endocrine Society: ICE/ENDO 2014 in Chicago reveals.

This improvement in blood pressure reportedly was accompanied by a reduction in blood glucose (sugar) levels after 12 weeks of treatment with the drug, which is under development by Germany-based Boehringer Ingelheim Pharma.

Advertisement

"Tight blood pressure control in patients with hypertension and Type 2 diabetes is known to reduce the risk of death and complications related to diabetes," said a study co-investigator, Afshin Salsali, MD, executive director of the Diabetes and Metabolism therapeutic area for Boehringer Ingelheim Pharma, which funded the study. "Our results suggest the potential to reduce the risk of cardiovascular events with long-term treatment."

However, he emphasized that this hypothesis awaits confirmation in the long-term EMPA-REG OUTCOMETM trial (NCT01131676 on ClinicalTrials.gov), which is expected to complete in 2015.
Advertisement

The researchers tested two doses of empagliflozin, 10 milligrams (mg) and 25 mg, compared to a placebo, or "dummy" pill, in patients with Type 2 diabetes and high blood pressure, which ranged from 130 over 80 to 159 over 99 millimeters of mercury (mm Hg). Of the 824 patients, 276 received the lower dose of empagliflozin and another 276 received the higher dose; 272 patients received the placebo. All patients wore a blood pressure cuff that monitored their blood pressure at regular intervals for 24 hours before the start of the study and after 12 weeks of treatment. They also gave blood samples for checking their hemoglobin A1c, a measure of long-term blood sugar control.

Study data showed the differences between the average decreases with empagliflozin treatment and the average increases in results of patients treated with placebo. Empagliflozin at the 25-mg dose demonstrated the greatest 12-week reduction in both systolic blood pressure (the top number in a blood pressure reading) and diastolic blood pressure (bottom number). On average, blood pressure fell 4.2 mm Hg in comparison to placebo for systolic pressure and 1.7 mm Hg for diastolic in the group receiving 25 mg of empagliflozin. Patients who received the 10-mg dose had average decreases of 3.4 and 1.4 mm Hg compared to placebo in systolic and diastolic blood pressures, respectively.

From the start to the end of the study, the average hemoglobin A1c level dropped 0.62 percentage points with 10-mg empagliflozin and 0.65 percentage points with the 25-mg dose compared to placebo.

Salsali said empagliflozin improves blood sugar levels by reducing glucose re-absorption in the kidneys, leading to glucose elimination in the urine. He also said patients tolerated the drug well, with no increased rate of side effects in the empagliflozin groups compared to placebo. Most adverse events reported in all three groups were mild in intensity.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
High Blood Pressure Drug Toxicity Thalassemia Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Diet Lifestyle and Heart Disease Diet and High Blood Pressure Signature Drug Toxicity Stress and the Gender Divide Stroke 

Recommended Reading
Diabetes - Foot Care
Valuable information on diabetic foot care, treatment and prevention....
Diabetes Diet Plan
Diet plays a significant role in controlling diabetes. Most cases of diabetes are preventable with ....
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces ......
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diet and High Blood Pressure
High blood pressure or hypertension is defined as a blood pressure of above 140 mm Hg (systolic) and...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
High Blood Pressure
High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it i...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to st...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use