Medindia
Advertisement

Exosome-based Antioxidant Therapy, a Possible Treatment for Parkinson's Disease

by Julia Samuel on May 6, 2015 at 5:52 PM

Exosome-based Antioxidant Therapy, a Possible Treatment for Parkinson's Disease
Researchers at University of North Carolina at Chapel Hill used exosomes, the vesicles that pass chemical messages between cells to transmit large therapeutic proteins across the blood-brain barrier to treat Parkinson's disease.

The blood-brain barrier prevents the passage of most therapeutic drugs to the organ. The barrier is very selective of what's allowed to pass through, but that does not hold good in the case of exosomes.
Advertisement

The investigators at Chapel Hill loaded used catalase, a powerful antioxidant into the exosomes, which were gathered from macrophage white blood cells. Delivering an antioxidant at the site of inflammation in the brain may be therapeutic as Parkinson's and many other neurological diseases cause inflammation in the brain.

The team sprayed the loaded exosomes on mice to test the delivery system and showed that they passed through the blood-brain barrier carrying the cargo. The brain cells readily took up the exosomes and the antioxidant provided significant neuro protective effects in vitro and in vivo models of Parkinson's Disease.

The study proved that exosome-based catalase formulations have a potential to be a versatile strategy to treat inflammatory and neurodegenerative disorders.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Food Additives Amyotrophic Lateral Sclerosis (ALS) Herbs and Antioxidants Mint It All! Quiz on Antioxidants Foods that Gives You Sparkling Eyes Berries for a Healthy and Beautiful You Anti-Aging Treatment with Vinotherapy or Wine Facials The Fruit in News – Guava Bael - The Ultimate Medicinal Summer Fruit 

Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Peppers and Parkinson’s Disease
Eating peppers at least twice a week could reduce the risk of Parkinson's disease, according to a .....
Newer Possible Treatment Approaches for Parkinson’s Disease
Researchers at Sweden's Lund University carried out a study on rats to reveal how Parkinson's ......
Novel Compound to Combat Parkinson’s Disease
A new compound called 12g developed by researchers was found to protect mice from motor deficits ......
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Anti-Aging Treatment with Vinotherapy or Wine Facials
Experience the bliss of vinotherapy - the power of grapes for a kissable skin....
Bael - The Ultimate Medicinal Summer Fruit
The bael is an important aromatic medicinal tree of Indian origin. Despite the goodness it packs in ...
Berries for a Healthy and Beautiful You
Antioxidants in the form of small berries packed with wonderful benefits…Find out how these tiny ber...
Food Additives
A food additive is a non-nutritive substance added deliberately to any food product to improve its c...
Foods that Gives You Sparkling Eyes
Food not only sustains us but the kind and quality of food determines the state of your health, whic...
Herbs and Antioxidants
Herbs are rich sources of anti-oxidants that help build your immune system. Reach out for your spice...
Mint It All!
A popular garden herb, mint has earned worldwide fame both in the kitchen as well as health. A tasty...
The Fruit in News – Guava
Anti-oxidant property of guava has recently been found be the highest amongst commonly consumed Indi...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use