About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Exercise Offers Protection Against Alzheimer's: Study

by Colleen Fleiss on July 17, 2019 at 5:59 AM
Font : A-A+

Exercise Offers Protection Against Alzheimer's: Study

In older people with Alzheimer's disease, increased levels of daily physical activity were found to protect against cognitive decline and neurodegeneration (brain tissue loss), revealed researchers from Massachusetts General Hospital (MGH) have found. In a paper in JAMA Neurology, the team also reported that lowering vascular risk factors may offer additional protection against Alzheimer's and delay progression of the devastating disease. The findings from this study will be presented at the Alzheimer's Association International Conference (AAIC) in Los Angeles by the first author of the study, Jennifer Rabin, PhD, now at the University of Toronto, Sunnybrook Research Institute.

Advertisement

"One of the most striking findings from our study was that greater physical activity not only appeared to have positive effects on slowing cognitive decline, but also on slowing the rate of brain tissue loss over time in normal people who had high levels of amyloid plaque in the brain," says Jasmeer Chhatwal, MD, PhD of the MGH Department of Neurology, and corresponding author of the study. The report suggests that physical activity might reduce b-amyloid (Ab)-related cortical thinning and preserve gray matter structure in regions of the brain that have been implicated in episodic memory loss and Alzheimer's-related neurodegeneration.

The pathophysiological process of AD begins decades before clinical symptoms emerge and is characterized by early accumulation of b-amyloid protein. The MGH study is among the first to demonstrate the protective effects of physical activity and vascular risk management in the "preclinical stage" of Alzheimer's disease, while there is an opportunity to intervene prior to the onset of substantial neuronal loss and clinical impairment. "Because there are currently no disease-modifying therapies for Alzheimer's disease, there is a critical need to identify potential risk-altering factors that might delay progression of the disease," says Chhatwal.
Advertisement

The Harvard Aging Brain Study at MGH assessed physical activity in its participants - 182 normal older adults, including those with elevated b-amyloid who were judged at high-risk of cognitive decline - through hip-mounted pedometers which counted the number of steps walked during the course of the day.

"Beneficial effects were seen at even modest levels of physical activity, but were most prominent at around 8,900 steps, which is only slightly less than the 10,000 many of us strive to achieve daily," notes co-author Reisa Sperling, MD, director of the Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital and Massachusetts General Hospital and co-principal investigator of the Harvard Aging Brain Study.

Interventional approaches that target vascular risk factors along with physical exercise have added beneficial properties, she adds, since both operate independently. Vascular risk factors measured by the researchers were drawn from the Framingham Cardiovascular Disease Risk Score Calculator, and include age, sex, weight, smoking/non-smoking, blood pressure, and whether people are on treatment for hypertension.

Through ongoing studies MGH is working to characterize other forms of physical activity and lifestyle changes that may help retard the progress of Alzheimer's disease. "Beta amyloid and tau protein build-up certainly set the stage for cognitive impairment in later age, but we shouldn't forget that there are steps we can take now to reduce the risk going forward - even in people with build-up of these proteins," says Chhatwal. "Alzheimer's disease and the emergence of cognitive decline is multifactorial and demands a multifactorial approach if we hope to change its trajectory."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ten Fruits for Diabetics
Natural Supplements Help Reverse Hair Loss during Menopause
Ways to Manage Stress during COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Lifestyle and Heart Disease Tips to Live Longer Exercise and Fitness Lifestyle Modification: No Big Deal! Body Types and Befitting Workouts Exercise To Gain Weight Top Health Tips to Overcome Tiredness Fitness Through Density Training Program Exercises to Grow Taller Exercise 

Recommended Reading
Benefits of Aerobic Exercises
Aerobics is a physical exercise that includes activities like dance, cycling, running, stretching .....
Test your Knowledge on Exercise Addiction
Exercise addiction, or exercise dependence, is a compulsive habit of engaging in an extreme ......
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and ......
Fitness and Exercise Calorie Calculator for Weight Loss
Fitness and Exercise Calorie Calculator for Weight Loss accurately estimates the number of calories ...
Body Types and Befitting Workouts
Workout and diet which is well suited for a pear shaped body....
Exercise
It is important for us to understand the power of daily exercise. Only then can we motivate ourselve...
Exercise and Fitness
Exercise is about revamping your lifestyle, not just weight loss. Exercise to get healthy – that way...
Exercise To Gain Weight
Are you underweight and want to know how to gain weight? Exercise or workouts can help you gain weig...
Exercises to Grow Taller
An article that highlights on the list of exercises that aids to grow taller....
Fitness through Density Training Program
Density Training is an effective weight training workout which helps to quickly build muscle and los...
Lifestyle Modification: No Big Deal!
Simple and practically possible lifestyle changes can make a huge difference in improving our health...
Tips to Live Longer
Though life is temporary and short, it is possible to maximize the span of our existence by living h...
Top Health Tips to Overcome Tiredness
If you follow a healthy lifestyle and still feel tired, you should rule out all possible medical cau...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use