About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Evolutionary History of Antibiotic Production & Resistance Revealed

by Ramya Rachamanti on August 13, 2019 at 8:14 PM
Font : A-A+

Evolutionary History of Antibiotic Production & Resistance Revealed

Natural history of antibiotic production and resistance is revealed by the team of researchers from the McMaster University. They also revealed that their co-emergence dates back to 350 to 500 million years.

The study which is published in Nature Microbiology, is the first to put antibiotic biosynthesis and resistance into an evolutionary context.

Advertisement


"Our findings are of significant interest," said Gerry Wright, senior author and professor of the Department of Biochemistry and Biomedical Sciences at McMaster. He is also director of the Michael G. DeGroote Institute for Infectious Disease Research and the newly established David Braley Centre for Antibiotic Discovery.

"Our study reveals several implications in how we could potentially manage antibiotic use and find new drugs for antimicrobial infections."

The team extracted this history by first identifying the genome sequences encoding all of the necessary genetic programs for the production of glycopeptide antibiotics within a group of bacteria called Actinobacteria. Glycopeptides include vancomycin and teicoplanin, essential medicines for treating bacterial infections.
Advertisement

Researchers then plotted the changes in these genetic programs over time, revealing that while the precursors for genes responsible for antibiotic production date back to over one billion years, resistance is contemporary with the production of the first ancestors of vancomycin-like drugs, dating back to 350 to 500 million years.

"The results we uncovered in this study offers a valuable lens through which to consider the current antibiotic crisis," said Nicholas Waglechner, first author and PhD candidate in the Gerry Wright lab. "These compounds have been useful to bacteria on the planet even before dinosaurs appeared, and resistance co-evolved with production as a means of self-protection for producing bacteria. The use of vancomycin in modern times in medicine and agriculture has resulted in the movement of resistance from these innocuous producers to disease-causing bacteria over a few short decades."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Antibiotics Eye Infections Natural Antibiotics to Fight Bacterial Infections Vancomycin-Resistant Enterococci (VRE) Boils - Treatment by Drugs Multiple Drug Allergy Syndrome Interaction of Antibiotics with Dairy Products 

Recommended Reading
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general featu...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like b...
Eye Infections
Eye infection is a common problem that often causes pain and discomfort to the eyes. Common symptoms...
Interaction of Antibiotics with Dairy Products
Antibiotics like tetracyclines and fluoroquinolones used in the treatment of bacterial infections in...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Multiple Drug Allergy Syndrome
Multiple drug allergy syndrome or multiple drug hypersensitivity syndrome is a condition that causes...
Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming medi...
Vancomycin-Resistant Enterococci (VRE)
Enterococci are a group of gram-negative bacteria that mostly inhabit the human gut. At present ther...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use