Compelling evidence has been found by an Evolutionary Biologist at The University of Manchester that parts of the brain can evolve independently from each other.
Compelling evidence has been found by an Evolutionary Biologist at The University of Manchester that parts of the brain can evolve independently from each other. It's hoped the findings will significantly advance our understanding of the brain.
The unique 15 year study with researchers at the University of Tennessee and Harvard Medical School also identified several genetic loci that control the size of different brain parts.
The aim of the research was to find out if different parts of the brain can respond independently of each other to evolutionary stimulus (mosaic evolution) or whether the brain responds as a whole (concerted evolution). Unlike previous studies the researchers compared the brain measurements within just one species. The findings have been published in the journal Nature Communications.
The brains of approximately 10,000 mice were analysed. Seven individual parts of each brain were measured by volume and weight. The entire genome, except the Y chromosome, was scanned for each animal and the gene set for each brain part identified.
Dr Reinmar Hager from the Faculty of Life Sciences compared variation in the size of the brain parts to variation in the genes. He found that the variation in the size of brain parts is controlled by the specific gene set for that brain part and not a shared set of genes.
He also compared the measurements for each mouse to the overall size of its brain. Surprisingly he found very little correlation between the sizes of the brain parts and the overall size of the brain.
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Using the data collected from the mice Dr Hager and colleagues analysed the genes that influence the size of the brain to the genes that control the size of the body. They wanted to find out how independent size regulation of the brain is to that of the body.
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The evidence means that overall brain size can evolve independently of body size.
Following this research more work will be carried out to identify the specific genes that underlie the size of different parts in the brain
Dr Hager says: "If we can identify the specific genes that cause variations in the size of brain parts then there will be big implications for researchers looking at neuronal disease and brain development. We hope this research will significantly advance our understanding of the brain."
Source-Eurekalert