Estradiol Better Than Conjugated Equine Estrogens Pills in Lowering Blood Clot Risk

by Kathy Jones on October 1, 2013 at 8:22 PM
Font : A-A+

 Estradiol Better Than Conjugated Equine Estrogens Pills in Lowering Blood Clot Risk

An observational study has found that using estradiol by post menopausal women leads to lower risk of developing blood clots in leg veins (deep vein thrombosis) and clots in the lungs (pulmonary emboli) compared to use of conjugated equine estrogens.

According to a joint University of Washington (UW)-Group Health study in JAMA Internal Medicine, women patients of Group Heath who were prescribed a generic version of estradiol—a bio-equivalent estrogen—experienced fewer adverse vascular events than did those prescribed conjugated equine estrogens, a patented drug marketed as Premarin.


"Although oral estrogens are effective for managing menopause symptoms, not enough is known about the cardiovascular safety of different oral hormone therapy products relative to each other," said first author Nicholas L. Smith, PhD. He is a professor of epidemiology at the UW School of Public Health, the director of the Veterans Affairs (VA) Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System, and an affiliate investigator at Group Health Research Institute.

To further understand the differences in risk, the researchers also measured clotting (coagulation) factors in the blood of women who did not develop a clot. The researchers found that, compared with estradiol users, conjugated equine estrogen users had levels of blood factors that made them more prone to form blood clots. The researchers also investigated other cardiovascular events:

  • The risk of having a heart attack was somewhat—but not significantly—higher in women using oral conjugated equine estrogens than in those using oral estradiol.
  • No difference was seen in the risk of stroke.

"If our results are confirmed," Dr. Smith added, "women seeking menopausal treatment and their providers would find this information helpful when selecting a drug." Menopausal symptoms include hot flashes, night sweats, and vaginal dryness, burning, and irritation.

This project, part of the Heart and Vascular Health study, involved 384 Group Health members, aged 30-79, who were taking oral estrogen for menopause symptoms from 2003 through 2009. On February 1, 2005, Group Health's formulary switched its preferred oral estrogen from conjugated equine estrogens to estradiol. The Heart and Vascular Health study is a case-control study, where Group Health members who develop cardiovascular events are matched with control members who do not.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Thalassemia Anticoagulants von Willebrand Disease Deep Vein Thrombosis Pulmonary Embolism Hemophilia Blood Clots Blood in Stools - Symptom Evaluation Bombay Blood Group 

Recommended Reading
Birth Control Pills
Oral contraceptive or birth control pills contain hormones that prevent pregnancy. It is one of the ...
Safe, Effective Male Contraceptive Pill - The Long Wait
A lot of research is going on all over the world to create a male birth control pill and soon, it .....
Anticoagulants prevent the clotting of blood in our body. They are administered orally or via ......
Blood Clots
An abnormal blood clot forms when there is damage to the lining of an artery or stagnation of blood ...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Deep Vein Thrombosis
A blood clot (thrombus) in the deep venous system of the leg leads to deep vein thrombosis (DVT). DV...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Hemophilia is a rare single gene, X- linked disorder, which tends to run in families....
Pulmonary Embolism
Pulmonary embolism (PE) is a complication that results from a block in the main artery supplying the...
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
von Willebrand Disease
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use